CAJ | 학술논문

目的：探讨左西孟旦对脓毒症休克并心肌抑制的临床治疗效果。方法将51例脓毒症休克合并心肌抑制患者随机分成治疗组和对照组，对照组在基础治疗上加米力农治疗，治疗组在基础治疗上加左西盂旦治疗。观察两组患者的治疗效果。结果与对照组比较，治疗组治疗后SVI、CI、LVSWI升高更明显，差异有统计学意义( P<0．05)， HR、Lac、NT-proBNP、EVLWI下降更明显，差异有统计学意义( P<0．05)。对照组治疗后SVRI升高较治疗组明显。治疗组机械通气时间、ICU住院时间较对照组明显缩短，差异有统计学意义( P<0．05)，两组患者住院病死率差异无统计学意义(P>0．05)。结论左西孟旦可以改善脓毒症休克并心肌抑制患者的心功能，降低血管外肺水，提高组织灌注及氧代谢、减少机械通气时间，缩短ICU住院时间。
목적：탐토좌서맹단대농독증휴극병심기억제적림상치료효과。방법장51례농독증휴극합병심기억제환자수궤분성치료조화대조조，대조조재기출치료상가미력농치료，치료조재기출치료상가좌서우단치료。관찰량조환자적치료효과。결과여대조조비교，치료조치료후SVI、CI、LVSWI승고경명현，차이유통계학의의( P<0．05)， HR、Lac、NT-proBNP、EVLWI하강경명현，차이유통계학의의( P<0．05)。대조조치료후SVRI승고교치료조명현。치료조궤계통기시간、ICU주원시간교대조조명현축단，차이유통계학의의( P<0．05)，량조환자주원병사솔차이무통계학의의(P>0．05)。결론좌서맹단가이개선농독증휴극병심기억제환자적심공능，강저혈관외폐수，제고조직관주급양대사、감소궤계통기시간，축단ICU주원시간。
Objective To investigate the clinical effect of levosimendan on septic shock and myocardial depression. Methods 51 cases of septic shock with myocardial depression patients were randomly divided into treatment group and control group. The control group received Milrinone treatment on the basis of the treatment. Treatment group received levosimendan treat-ment on the basis of the treatment. To observe the therapeutic effect of two groups of patients. Results Compared with the control group,after the treatment in the treatment group,SVI,CI,LVSWI were significantly increased(P<0. 05),HR,Lac,NT-proBNP, EVLWI were significantly decreased(P<0. 05). Compared with the treatment group,after the treatment in the control group,SVRI was significantly increased(P<0. 05). Compared with the control group,in the treatment group,the mechanical ventilation time and the length of stay in ICU,were significantly shorter(P<0. 05),the two groups showed no significant difference in hospital mor-tality(P>0. 05). Conclusion levosimendan can improve heart function,reduce extravascular lung water,improve tissue perfu-sion and oxygen metabolism,reduce mechanical ventilation time,shorten the length of stay in ICU of patients with septic shock and cardiac depression.