CAJ | 학술논문

目的：研究参卿止痒洗液对慢性湿疹的作用,为临床合理运用提供可靠参考。方法给小鼠皮肤多次涂抹2,4-二硝基氟苯(DNFB)以复制慢性湿疹模型。同时给予不同浓度的参卿止痒洗液观察药物的作用。结果模型组小鼠在激发后背部皮肤逐渐增厚、粗糙、干燥,有血痂,激发部位有少量毛发生长；动物表现出烦躁不安,回头频率增高,小鼠背部皮肤表皮增厚,皮肤炎性细胞浸润明显增多；而参卿止痒洗液2倍临床浓度、参卿止痒洗液临床浓度(原液)、参卿止痒洗液0．5倍临床浓度等各剂量组较模型组的小鼠皮肤增厚减轻,不干燥,激发部位毛发几乎都生长,小鼠行为也较安静,回头舔舐情况也少；参卿止痒洗液可显著抑制DNFB致小鼠皮肤表皮增厚,抑制炎细胞浸润,与模型组比较差异有统计学意义。结论上述结果提示参卿止痒洗液对慢性湿疹具有一定的防治作用,其详细作用机理有待进一步探讨。
목적：연구삼경지양세액대만성습진적작용,위림상합리운용제공가고삼고。방법급소서피부다차도말2,4-이초기불분(DNFB)이복제만성습진모형。동시급여불동농도적삼경지양세액관찰약물적작용。결과모형조소서재격발후배부피부축점증후、조조、간조,유혈가,격발부위유소량모발생장；동물표현출번조불안,회두빈솔증고,소서배부피부표피증후,피부염성세포침윤명현증다；이삼경지양세액2배림상농도、삼경지양세액림상농도(원액)、삼경지양세액0．5배림상농도등각제량조교모형조적소서피부증후감경,불간조,격발부위모발궤호도생장,소서행위야교안정,회두첨지정황야소；삼경지양세액가현저억제DNFB치소서피부표피증후,억제염세포침윤,여모형조비교차이유통계학의의。결론상술결과제시삼경지양세액대만성습진구유일정적방치작용,기상세작용궤리유대진일보탐토。
Objective To study the therapeutic effect of Shengqing anti-itch lotion against chronic eczema,providing reli-able references to clinical treatment. Methods repeatedly paint 2,4-DNFB(dinitrofluorobenzene)on the skin of mice to replicate chronic eczema model, meanwhile add Shengqing anti-itch lotion of different concentration for the purpose of inspect the drug effect. Results After the model mice was stimulated,its back skin gradually thicken and became rough and dry,carrying with blood scab on its surface. And there was just a small amount of hair remaining growing on it. The mice appeared to be agitated and kept turning round frequently,and the skin of its back thicken,skin inflammatory cell infiltration obviously increased. Compared with the skin of mice of model group,the mice skin of dosage groups carrying Shengqing anti-itch lotion that was twice as much as the dosage for clinical application,that was the same as the dosage for clinical application,and that was half of the dosage for clini-cal application,appeared to thicken less seriously and showed no dryness. And almost all hair in the stimulated parts remained growing. As for the behaviors,the mice were relatively quiet,and would not turn round to lick as frequently as the model mice would. Shengqing anti-itch lotion can obviously inhibit DNFB from thickening the skin of mice and inflammatory cell infiltration. There are some differences between dosage groups and model groups statistically(P<0. 05). Conclusion Shengqing anti-itch lo-tion possesses certain preventive and therapeutic effect against chronic eczema;the mechanism of action remains to be further dis-cussed.