CAJ | 학술논문

选取腈化合物和醛化合物为研究对象，以明亮发光杆菌为模式生物，以15 min发光抑制为测定终点，测定了10种腈醛化合物的单一急性毒性和55组二元非等毒性比腈醛混合体系的联合毒性，分别建立了腈、醛化合物单一急性毒性的QSAR模型，并提出了非等毒性比腈醛混合化合物对发光菌联合毒性的QSAR模型。结果表明，不同的腈醛混合化合物对发光菌的联合毒性不同，主要呈现协同作用和相加作用。采用QSAR模型定量描述了腈醛类化合物对明亮发光杆菌的联合毒性作用，为环境介质中腈醛的联合生态风险评价和修复提供了理论依据。
선취정화합물화철화합물위연구대상，이명량발광간균위모식생물，이15 min발광억제위측정종점，측정료10충정철화합물적단일급성독성화55조이원비등독성비정철혼합체계적연합독성，분별건립료정、철화합물단일급성독성적QSAR모형，병제출료비등독성비정철혼합화합물대발광균연합독성적QSAR모형。결과표명，불동적정철혼합화합물대발광균적연합독성불동，주요정현협동작용화상가작용。채용QSAR모형정량묘술료정철류화합물대명량발광간균적연합독성작용，위배경개질중정철적연합생태풍험평개화수복제공료이론의거。
It is widely accepted that organisms are often exposed to mixtures of multiple pollutants rather than to single chemical in the envi-ronment, such as cyanogenic chemicals and aldehydes. The interactions among the components in the pollutant mixtures might cause sub-stantial changes in their apparent properties, leading to additive, synergistic or antagonistic effects, and thus posing potential threats on the environmental safety and human health. In this paper, cyanogenic chemicals and aldehydes were selected as the research chemicals and Photobacterium phosphoreum as a model organism. The acute toxicity of cyanogenic and aldehyde compounds to Photobacterium phospho-reum was tested based on the light emitting reaction in bioluminescence. General approaches were therefore proposed to predict the biologi-cal toxicity of chemical mixtures with different toxicity processes by using effective carbon charge and substituent constant. The QSAR mod-els for acute toxicity of cyanogenic chemicals and aldehydes alone and in mixture were established. The mechanisms of mixed toxicity of cyanogenic chemicals and aldehydes were suggested. Results demonstrated that the joint toxicity changed with different mixtures of cyanogenic chemicals and aldehydes, which showed additive and synergistic effects. This work would provide basic information for the joint ecological risk assessment and remediation of cyanogenic chemicals and aldehydes.