CAJ | 학술논문

目的：探讨血清胱抑素C（CysC）与尿微量清蛋白（mALB）联合检测对早期糖尿病肾病损伤的诊断价值。方法对120例2型糖尿病患者和40例健康人的CysC与mALB及相关临床生化指标，并对各因素进行相关性分析，探讨糖尿病早期肾功能损害者与健康人的差异。结果早期糖尿病肾病组、临床糖尿病肾病组CysC和mALB高于健康对照组，差异有统计学意义（P＜0．05），mALB与血清CysC水平呈正相关（r＝0．662，P＜0．05），血清Cr、BUN水平与mALB无明显相关。结论 CysC与mALB是反映早期肾功能损伤的敏感而可靠的指标，CysC与mALB联合检测有助于肾病的早期诊断、疗效观察及预后判断。
목적：탐토혈청광억소C（CysC）여뇨미량청단백（mALB）연합검측대조기당뇨병신병손상적진단개치。방법대120례2형당뇨병환자화40례건강인적CysC여mALB급상관림상생화지표，병대각인소진행상관성분석，탐토당뇨병조기신공능손해자여건강인적차이。결과조기당뇨병신병조、림상당뇨병신병조CysC화mALB고우건강대조조，차이유통계학의의（P＜0．05），mALB여혈청CysC수평정정상관（r＝0．662，P＜0．05），혈청Cr、BUN수평여mALB무명현상관。결론 CysC여mALB시반영조기신공능손상적민감이가고적지표，CysC여mALB연합검측유조우신병적조기진단、료효관찰급예후판단。
Objective To investigate the serum cystatin C (CysC) and urinary albumin excretion (mALB) joint detection in di‐agnosis of early diabetic nephropathy injury .Methods 120 cases of determination of CysC and microalbuminuria in type 2 diabetic patients and 40 healthy people and related clinical and biochemical parameters were measured ,and the various factors by correlation analysis ,the determination of differences in early renal damage in diabetes and healthy people .Results the early diabetic nephropa‐thy group ,diabetic nephropathy group serum cystatin C and urinary microalbumin is higher than the normal control group ,CysC and mALB level had significant difference ,the difference was statistically significant (P<0 .05) ,the mALB was positively correla‐ted with serum CysC levels (r=0 .662 ,P<0 .05) ,and no obvious correlation of serum Cr ,BUN levels and mALB .Conclusion trace albumin serum cystatin C and urine is reflecting early renal function injury sensitive and reliable index ,serum cystatin C com‐bined detection of urine micro albumin contributes to kidney disease early diagnosis ,treatment and prognosis judgement .