CAJ | 학술논문

目的：探讨不同病原感染性疾病患儿血清降钙素原（PCT）、C反应蛋白（CRP）及白细胞计数（WBC）的变化及诊断价值。方法回顾性分析2013年6月至2014年5月该院儿科确诊的94例感染性患儿，根据病原体检测结果分为细菌感染组36例，支原体感染组28例，病毒感染组30例，于入院时检测患儿血清PCT、CRP及WBC水平并进行统计学分析。结果细菌感染组患儿血清PCT、CRP及WBC分别为（2．41±0．94）ng／mL、（47．91±18．26）mg／L及（13．18±6．03）×109／L ，明显高于支原体感染组及病毒感染组，差异有统计学意义（F＝133．4，F＝60．1，F＝8．5，P＜0．05）；在细菌性感染诊断中PCT灵敏度及特异度分别为92．11％及91．05％，阳性、阴性预测值为89．84％及94．01％均明显高于CPR及WBC。以支原体感染组为对照，PCT、CRP及WBC在诊断细菌性感染ROC曲线下面积分别为0．816、0．728及0．614。结论血清PCT对于鉴别细菌性感染中有较高的诊断价值，值得推广应用。
목적：탐토불동병원감염성질병환인혈청강개소원（PCT）、C반응단백（CRP）급백세포계수（WBC）적변화급진단개치。방법회고성분석2013년6월지2014년5월해원인과학진적94례감염성환인，근거병원체검측결과분위세균감염조36례，지원체감염조28례，병독감염조30례，우입원시검측환인혈청PCT、CRP급WBC수평병진행통계학분석。결과세균감염조환인혈청PCT、CRP급WBC분별위（2．41±0．94）ng／mL、（47．91±18．26）mg／L급（13．18±6．03）×109／L ，명현고우지원체감염조급병독감염조，차이유통계학의의（F＝133．4，F＝60．1，F＝8．5，P＜0．05）；재세균성감염진단중PCT령민도급특이도분별위92．11％급91．05％，양성、음성예측치위89．84％급94．01％균명현고우CPR급WBC。이지원체감염조위대조，PCT、CRP급WBC재진단세균성감염ROC곡선하면적분별위0．816、0．728급0．614。결론혈청PCT대우감별세균성감염중유교고적진단개치，치득추엄응용。
Objective To explore the diagnostic value of serum procalcitonin ,C‐reactive protein and white blood cell count in children with different diseases .Methods Retrospective analysis 94 cases of pathogenic infectious children from June 2013 to May 2014 in our hospital ,according to the results of pathogen detection was divided into bacterial infection 36 cases ,mycoplasma infec‐tion group 28 cases ,30 cases of viral infection ,detection and analysis serum PCT ,CRP and WBC levels .Results Bacterial infection group serum PCT ,CRP and WBC were (2 .41 ± 0 .94)ng/mL ,(47 .91 ± 18 .26)mg/L and (13 .18 ± 6 .03) × 109/L ,significantly higher than the mycoplasma infection and viral infection group (F=133 .4 ,F=60 .1 ,F=8 .5 ,P<0 .05);diagnosis of bacterial in‐fections ,PCT sensitivity and specificity were 92 .11% and 91 .05% ,positive and negative predictive value of 89 .84 % and 94 .01%were significantly higher than CPR and WBC ,Mycoplasma infection as the control group ,PCT ,CRP and WBC in the diagnosis of bacterial infections ,the area of under the ROC curves were 0 .816 ,0 .728 and 0 .614 ,respectively .Conclusion Serum PCT for the i‐dentification of bacterial infections has a high diagnostic value ,worth generalizing and applying .