CAJ | 학술논문

目的：本研究旨在观察机动车尾气对大鼠气道高反应性的影响。方法：取30只 SD 大鼠，随机分5组：正常对照组；吸入尾气2天组；吸入尾气4天组；吸入尾气6天组；吸入尾气8天组，每组6只。采用小动物呼吸机，肺组织切片 PAS 和 HE 染色，检测各组大鼠呼吸道反应性，肺组织杯状细胞化生指数、上皮粘液储备指数和炎症细胞数量。结果：随着尾气吸入时间的延长，大鼠出现越来越明显的气道高反应性，同时，呼吸道粘液分泌量显著增加，气道炎症明显加重。结论：吸入机动车尾气能引发并加重气道高反应性。
목적：본연구지재관찰궤동차미기대대서기도고반응성적영향。방법：취30지 SD 대서，수궤분5조：정상대조조；흡입미기2천조；흡입미기4천조；흡입미기6천조；흡입미기8천조，매조6지。채용소동물호흡궤，폐조직절편 PAS 화 HE 염색，검측각조대서호흡도반응성，폐조직배상세포화생지수、상피점액저비지수화염증세포수량。결과：수착미기흡입시간적연장，대서출현월래월명현적기도고반응성，동시，호흡도점액분비량현저증가，기도염증명현가중。결론：흡입궤동차미기능인발병가중기도고반응성。
Objective This study was designed to observe the impacts of the motor vehicle exhausts to airway hyperrespon-siveness in rats. Methods 30 Wister rats were randomly divided into 5 groups: normal control group; exhausts inhalation group for two days, four days, six days and eight days, 6 rats in each group on average. Rodent ventilator and the technology of HE and PAS stainings were used to observe the airway responsiveness in the lungs, the metaplasia of goblet cells index, the epithelial mucous reserve index, the amount of inflammatory cells. Results With the time of exhausts inhalation extension, the airway hy-perresponsiveness is becoming more evident, while the amount of secretions of the airway mucus is increased rapidly; the airway inflammation is become serious evidently. Conclusion The results given above reveal that the airway hyperresponsiveness could be incurred and exacerbated through inhaling the motor vehicle exhausts.