CAJ | 학술논문

目的：探讨围绝经期妇女焦虑、抑郁障碍的主要临床特征及相关影响因素。方法采用HAMD和HAMA对57例首次入院治疗的围绝经期焦虑、抑郁障碍患者进行临床症状评估，生活事件量表（LES）评估，以及检测每位患者体内激素水平，并用描述性统计、Spearman相关分析、多元线性逐步回归分析结果。结果57例患者的HAMD总分为（22．56±8．48）分，HAMA总分为（15．21±7．88）分，主要集中于轻到中度抑郁和明确的焦虑。其中大多数患者受到生活事件的影响，以负性生活事件为主。线性相关分析发现，绝经后发病与抑郁障碍正相关，差异有统计学意义的相关系数为0．275；焦虑障碍无明显相关因素。线性回归分析发现，雌二醇与抑郁障碍负相关，垂体泌乳素、家庭经济困难、子女长期离家与抑郁障碍正相关，差异有统计学意义的回归系数依次为－0．823、0．230、1．017、0．783；家庭经济困难、夫妻感情不好与焦虑障碍正相关，差异有统计学意义的回归系数为0．802、0．553。结论围绝经期妇女焦虑、抑郁障碍多以轻到中度为主，受激素及社会家庭因素的影响。
목적：탐토위절경기부녀초필、억욱장애적주요림상특정급상관영향인소。방법채용HAMD화HAMA대57례수차입원치료적위절경기초필、억욱장애환자진행림상증상평고，생활사건량표（LES）평고，이급검측매위환자체내격소수평，병용묘술성통계、Spearman상관분석、다원선성축보회귀분석결과。결과57례환자적HAMD총분위（22．56±8．48）분，HAMA총분위（15．21±7．88）분，주요집중우경도중도억욱화명학적초필。기중대다수환자수도생활사건적영향，이부성생활사건위주。선성상관분석발현，절경후발병여억욱장애정상관，차이유통계학의의적상관계수위0．275；초필장애무명현상관인소。선성회귀분석발현，자이순여억욱장애부상관，수체비유소、가정경제곤난、자녀장기리가여억욱장애정상관，차이유통계학의의적회귀계수의차위－0．823、0．230、1．017、0．783；가정경제곤난、부처감정불호여초필장애정상관，차이유통계학의의적회귀계수위0．802、0．553。결론위절경기부녀초필、억욱장애다이경도중도위주，수격소급사회가정인소적영향。
Objective To investigate the clinical features of depression and anxiety disorders and their influence factors in women during perimenopause .Methods Fifty-seven cases of first hospitalized perimenopausal patients with anxiety and depression symptoms evaluated by Hamilton Depression Rating Scale for Depression (HAMD) ,Hamilton Anxiety Scale for Anxiety (HAMA) and Life Event Scale (LES) ,and detected of hormone levels .All of the data were input into a database and analyzed with de‐scriptive statistics ,Spearman correlation analysis and multiple linear regression analysis .Results All 57 patients in the HAMD total score of (22 .56 ± 8 .48) ,HAMA total score of (15 .21 ± 7 .88) ,mainly mild or moderate depression and definite anxiety .Most of the patients affected by life events ,especial the negative life events .Linear correlation analysis showed that the incidence of postmenopausal was posi‐tively correlated with depressive disorder ,the correlation coefficient was 0 .275;there was no significant correlation factor with anxiety disorders .Linear regression analysis showed that estradiol was negatively correlation with depressive disorders;pituitary prolactin ,economically disadvantaged families ,children long - term leaving home was positively correlated with depression (the regression coefficients were-0 .823 ,0 .230 ,1 .017 ,0 .783 ,respectively);economically disadvantaged families ,bad marital relations was positively correlated with anxiety disorders (the regression coefficient were 0 .802 ,0 .553) .Conclu‐sions Perimenopausal women were mainly in mild or moderate anxiety and depression ,were affected by hormones and social family factors .