神经疾病与精神卫生
神經疾病與精神衛生
신경질병여정신위생
NERVOUS DISEASES AND MENTAL HYGIENE
2015年
3期
225-227
,共3页
崔萌%亢小燕%庄蓉%蒋东%曾波涛
崔萌%亢小燕%莊蓉%蔣東%曾波濤
최맹%항소연%장용%장동%증파도
精神分裂症%同型半胱氨酸%事件相关电位%精神病学
精神分裂癥%同型半胱氨痠%事件相關電位%精神病學
정신분렬증%동형반광안산%사건상관전위%정신병학
Schizophrenia%Homocysteine%Event-related potential%Psychiatry
目的:研究首发精神分裂症患者血清叶酸及同型半胱氨酸与P300的相关性。方法选取50例首发精神分裂症患者作为患者组,在医院职工和社区人群中选取年龄、性别相匹配的50名健康人作为对照组,分别测定所有被试的血清叶酸及同型半胱氨酸和 P300,应用阳性和阴性症状量表(PANSS)评定患者组入组时精神症状。结果患者组血清叶酸水平低于对照组,差异有统计学意义(t =5.14,P <0.01);血清同型半胱氨酸高于对照组,差异有统计学意义(t =4.23,P<0.01);患者组P300波幅低于对照组而潜伏期高于对照组,差异有统计学意义( t =2.51~3.23,P <0.05)。患者组血清叶酸水平与各位点P300波幅及潜伏期均无相关性。患者组血清同型半胱氨酸水平与Cz、Pz位点P300潜伏期呈正相关( r=0.36~0.46,P<0.05),患者组血清同型半胱氨酸水平与Cz、Pz点P300波幅则呈负相关( r =-0.38~-0.51,P<0.05)。结论首发精神分裂症患者P300的波幅和潜伏期变化可能与血清同型半胱氨酸代谢异常有关,而与血清叶酸水平无直接相关性。
目的:研究首髮精神分裂癥患者血清葉痠及同型半胱氨痠與P300的相關性。方法選取50例首髮精神分裂癥患者作為患者組,在醫院職工和社區人群中選取年齡、性彆相匹配的50名健康人作為對照組,分彆測定所有被試的血清葉痠及同型半胱氨痠和 P300,應用暘性和陰性癥狀量錶(PANSS)評定患者組入組時精神癥狀。結果患者組血清葉痠水平低于對照組,差異有統計學意義(t =5.14,P <0.01);血清同型半胱氨痠高于對照組,差異有統計學意義(t =4.23,P<0.01);患者組P300波幅低于對照組而潛伏期高于對照組,差異有統計學意義( t =2.51~3.23,P <0.05)。患者組血清葉痠水平與各位點P300波幅及潛伏期均無相關性。患者組血清同型半胱氨痠水平與Cz、Pz位點P300潛伏期呈正相關( r=0.36~0.46,P<0.05),患者組血清同型半胱氨痠水平與Cz、Pz點P300波幅則呈負相關( r =-0.38~-0.51,P<0.05)。結論首髮精神分裂癥患者P300的波幅和潛伏期變化可能與血清同型半胱氨痠代謝異常有關,而與血清葉痠水平無直接相關性。
목적:연구수발정신분렬증환자혈청협산급동형반광안산여P300적상관성。방법선취50례수발정신분렬증환자작위환자조,재의원직공화사구인군중선취년령、성별상필배적50명건강인작위대조조,분별측정소유피시적혈청협산급동형반광안산화 P300,응용양성화음성증상량표(PANSS)평정환자조입조시정신증상。결과환자조혈청협산수평저우대조조,차이유통계학의의(t =5.14,P <0.01);혈청동형반광안산고우대조조,차이유통계학의의(t =4.23,P<0.01);환자조P300파폭저우대조조이잠복기고우대조조,차이유통계학의의( t =2.51~3.23,P <0.05)。환자조혈청협산수평여각위점P300파폭급잠복기균무상관성。환자조혈청동형반광안산수평여Cz、Pz위점P300잠복기정정상관( r=0.36~0.46,P<0.05),환자조혈청동형반광안산수평여Cz、Pz점P300파폭칙정부상관( r =-0.38~-0.51,P<0.05)。결론수발정신분렬증환자P300적파폭화잠복기변화가능여혈청동형반광안산대사이상유관,이여혈청협산수평무직접상관성。
Objective To explore the correlation between serum homocysteine ,folate and P300 in first-episode schizophrenia patients .Methods Fifty patients with first -episode schizophrenia were se‐lected as patient group ,choosing the age and sex -matched 50 healthy people in hospital staff and com‐munity groups as control group ,all participants were sepatately tested serum folate ,homocysteine and P300 ,and assessing psychotic symptoms when patients enrolled by Positive and Negative Syndrome Scale(PANSS) .Results Compared with the control group ,the level of serum folate was lower than in patient group ,the difference was statistically significant (t=5 .14 ,P<0 .01);Serum homocysteine was higher than the control group ,the difference was statistically significant (t=4 .23 ,P<0 .01);Compared with the control group ,P300 amplitude was lower and the incubation period was higher in patient group , and the difference was statistically significant (t=2 .51 -3 .23 ,P<0 .05) .In patient group ,serum ho‐mocysteine and Cz ,Pz site of P300 latency was positively correlated (r=0 .36~0 .46 ,P<0 .05) ,serum homocysteine and Cz ,Pz point of P300 amplitude was negatively correlated (r= -0 .38 - -0 .51 ,P<0.05) .Conclusions The amplitude and latency of P300's changes in first-episode schizophrenia patients may be associated with serum homocysteine metabolism ,and with no direct correlation with serum folate levels .