CAJ | 학술논문

热激蛋白（HSP）是生物体内高度进化保守的蛋白质家族，在多种应激条件下可被诱导产生，拥有复杂的生物学意义。 HSP作为分子伴侣，参与蛋白质的折叠、转运、合成等过程，调节细胞内肽类蛋白质的结合及各种细胞损伤的修复，在多种疾病过程中发挥重要作用。近年来发现HSP27在肿瘤中广泛表达，并参与肿瘤的发生、转移以及耐药等多个方面。对这些机制的深入探索有望为肿瘤治疗提供新的策略和选择。
열격단백（HSP）시생물체내고도진화보수적단백질가족，재다충응격조건하가피유도산생，옹유복잡적생물학의의。 HSP작위분자반려，삼여단백질적절첩、전운、합성등과정，조절세포내태류단백질적결합급각충세포손상적수복，재다충질병과정중발휘중요작용。근년래발현HSP27재종류중엄범표체，병삼여종류적발생、전이이급내약등다개방면。대저사궤제적심입탐색유망위종류치료제공신적책략화선택。
Heat shock protein( HSP) is evolutionarily conserved family of proteins in vivo whose expres-sion is induced in response to a wide variety of environmental insults , and has complex biological signifi-cance.As a chaperone,HSP plays an important role in a variety of disease processes by participating in pro-tein folding,transport and synthesis,the binding of intracellular peptides,and repair of various cell injuries. Recently,a lot of research have found that HSP27 is widely expressed in various tumors,involved in tumor development,drug resistance and metastasis.Therefore, understanding of these mechanisms is expected to provide new strategies and choices for anti-tumor therapy.