CAJ | 학술논문

白细胞介素2（IL－23）／IL－17轴是炎症免疫反应中的重要信号通路，大量研究表明 IL－23／IL－17轴在多种疾病中起重要作用。近年蛋白质组学研究证实 IL－23／IL－17轴中的重要因子 IL－23、IL－17在人类大肠癌细胞中呈过表达现象，并认为IL－23、IL－17的表达与大肠肿瘤的发生、发展密切相关。近年来，随着大肠癌研究逐渐深入，许多与大肠癌的相关的信号通路已经被发现，其中 IL－23／IL－17信号通路在大肠癌的发生发展过程中可能担当着重要角色。进一步深入研究 IL－23／IL－17信号通路轴中重要因子及它们的基因多态性等与大肠癌的关系，对筛选大肠癌高危人群、预防发病风险及治疗等有重大意义。
백세포개소2（IL－23）／IL－17축시염증면역반응중적중요신호통로，대량연구표명 IL－23／IL－17축재다충질병중기중요작용。근년단백질조학연구증실 IL－23／IL－17축중적중요인자 IL－23、IL－17재인류대장암세포중정과표체현상，병인위IL－23、IL－17적표체여대장종류적발생、발전밀절상관。근년래，수착대장암연구축점심입，허다여대장암적상관적신호통로이경피발현，기중 IL－23／IL－17신호통로재대장암적발생발전과정중가능담당착중요각색。진일보심입연구 IL－23／IL－17신호통로축중중요인자급타문적기인다태성등여대장암적관계，대사선대장암고위인군、예방발병풍험급치료등유중대의의。
Interleukin(IL)-23/IL-17 axis signaling pathway is an important signaling pathway in inflam-matory immune response,a large number of studies have shown that IL-23/IL-17 axis play an important role in many diseases.Recent proteomics studies confirm that IL-23 and IL-17,the important factor in IL-23/IL-17 axis signaling pathway are overexpressed in human colorectal cancer cells,and the expression of IL-23 and IL-17 are correlated to the occurrence and development of colorectal tumor cells.In recent years, with the deepening of colorectal cancer research,many signaling pathways have been found associated with color-ectal cancer.IL-23/IL-17 signaling pathway may play an important role in the process of development of colo-rectal cancer.Further research into the relation between important factors and their gene polymorphisms in IL-23/IL-17 axis signaling pathway and colorectal cancer and using it for screening of high-risk groups,pre-vention and treatment of colorectal cancer, have great significance.