CAJ | 학술논문

糖皮质激素诱导的亮氨酸拉链蛋白（GILZ）广泛地表达于各种细胞及组织中，有助于发挥糖皮质激素的抗炎效应和免疫抑制作用。 GILZ可抑制核因子κB、转录激活因子1及丝裂原活化蛋白激酶的激酶／细胞外信号调节激酶等炎症相关信号通路的活性，对巨噬细胞、树突细胞、内皮细胞、T淋巴细胞等炎性细胞的活性具有抑制作用。在慢性炎症反应中，GILZ的上调可抑制细胞因子和趋化因子的表达、白细胞的聚集和活化，并与类风湿关节炎等自身免疫性疾病密切相关。近年来对GILZ的研究众多，该文对GILZ与炎症反应相关的信号通路、细胞及相关疾病进行综述。
당피질격소유도적량안산랍련단백（GILZ）엄범지표체우각충세포급조직중，유조우발휘당피질격소적항염효응화면역억제작용。 GILZ가억제핵인자κB、전록격활인자1급사렬원활화단백격매적격매／세포외신호조절격매등염증상관신호통로적활성，대거서세포、수돌세포、내피세포、T림파세포등염성세포적활성구유억제작용。재만성염증반응중，GILZ적상조가억제세포인자화추화인자적표체、백세포적취집화활화，병여류풍습관절염등자신면역성질병밀절상관。근년래대GILZ적연구음다，해문대GILZ여염증반응상관적신호통로、세포급상관질병진행종술。
Glucocorticoid induced leucine zipper(GILZ) is widely expressed in various kinds of cells and tissues,and it promotes the anti-inflammatory and immune inhibitory effect of glucocorticoid .GILZ can inhibit the activity of inflammation-related signaling pathways,such as nuclear factor κB,AP-1 and mitogen-activated protein kinases kinases/extracellular regulated protein kinases.Besides,it can interfere with the activity of some inflammatory cells,such as the macrophages,dendritic cells, endothelial cells,T lymphocytes and so on.In chronic inflammation,the up-regulation of GILZ can inhibit the expression of cytokines and che-mokines,as well as the aggregation and activation of leukocyte.Furthermore,it is closely associated with auto-immune diseases,such as rheumatoid arthritis disease.There has been a lot of studies on GILZ in recent years,here is to make a review of the relationship between GILZ and the signal pathways,cells,diseases related with inflammation reactions.