CAJ | 학술논문

沉默信息调节因子2相关酶1（Sirt1）是一种依赖于烟酰胺腺嘌呤二核苷酸的Ⅲ类组蛋白脱乙酰化酶，为哺乳动物Sirtuin家族成员之一。 Sirt1可通过将组蛋白及多种非组蛋白去乙酰化，从而实现对基因转录、细胞生长周期调节、炎症反应以及能量代谢等多种信号通路的调节，进而参与细胞衰老、代谢稳态调节、自身免疫及肿瘤等一系列生理病理过程。随着研究的深入，Sirt1将有望在新药作用靶点及疾病治疗方面发挥作用。
침묵신식조절인자2상관매1（Sirt1）시일충의뢰우연선알선표령이핵감산적Ⅲ류조단백탈을선화매，위포유동물Sirtuin가족성원지일。 Sirt1가통과장조단백급다충비조단백거을선화，종이실현대기인전록、세포생장주기조절、염증반응이급능량대사등다충신호통로적조절，진이삼여세포쇠로、대사은태조절、자신면역급종류등일계렬생리병리과정。수착연구적심입，Sirt1장유망재신약작용파점급질병치료방면발휘작용。
The silent information regulator 2 homolog 1(Sirt1),a member of the mammalian surtuin fam-ily,is a NAD﹢-dependent histone deacetylase of class Ⅲ.Sirt 1 regulates various signaling pathways of gene transcription,cell cycle regulation,inflammatory response and energy metabolism ,which in turn is involved in a series of physiological and pathological processes such as cellular senescence ,metabolic homeostasis adjust-ment,autoimmune,and tumor.Along with thein-depth research,Sirt1 may be used as a novel drug target or applied in treatment of related diseases.