CAJ | 학술논문

高脂血症是导致动脉粥样硬化形成的主要因素。高脂血症通过作用于血小板，影响其活化、聚集等作用，进而影响动脉血栓形成。而采用他汀干预高脂血症后可改善血小板的活化功能，提示高脂血症与血小板活化密切相关。低密度脂蛋白胆固醇及高密度脂蛋白胆固醇可通过作用于血小板活化通路而影响血小板的活化聚集。该文就近年来高脂血症与血小板活化关系的研究进展予以综述。
고지혈증시도치동맥죽양경화형성적주요인소。고지혈증통과작용우혈소판，영향기활화、취집등작용，진이영향동맥혈전형성。이채용타정간예고지혈증후가개선혈소판적활화공능，제시고지혈증여혈소판활화밀절상관。저밀도지단백담고순급고밀도지단백담고순가통과작용우혈소판활화통로이영향혈소판적활화취집。해문취근년래고지혈증여혈소판활화관계적연구진전여이종술。
Hyperlipidemia is the main factor of the formation of atherosclerosis.Moreover, hyperlipidemia effects on platelet,influences the function of activation and aggregation,therefore influences the formation of atherosclerosis.By administration of statin to hyperlipidemia,it improves the platelet function,which indicates that hyperlipidemia is highly associated with platelet activation .Low-density lipoprotein cholesterol and high-density lipoprotein cholesterol influence platelet function through the impact of platelet signaling pathways . Here is to make review of the research progress of correlation between hyperlipidemia and platelet activation in recent years.