CAJ | 학술논문

丙型肝炎病毒（ HCV）感染是全球关注的公共健康问题之一。只有建立稳定可靠的 HCV感染模型，才能更好地研究HCV感染慢性化和致癌的机制，从而推动丙型肝炎疫苗的研制和抗丙型肝炎药物的筛选。 HCV宿主范围特别狭窄，只有人和黑猩猩对其易患。目前有一些体内和体外的实验结果初步显示，树鼩是目前继黑猩猩之后唯一能感染HCV的动物。该文对 HCV感染树鼩动物模型的研究进展予以行综述。
병형간염병독（ HCV）감염시전구관주적공공건강문제지일。지유건립은정가고적 HCV감염모형，재능경호지연구HCV감염만성화화치암적궤제，종이추동병형간염역묘적연제화항병형간염약물적사선。 HCV숙주범위특별협착，지유인화흑성성대기역환。목전유일사체내화체외적실험결과초보현시，수구시목전계흑성성지후유일능감염HCV적동물。해문대 HCV감염수구동물모형적연구진전여이행종술。
Hepatitis C virus( HCV) infection is one of the serious public health problems concerned all over the world.Only through establishing a stable and reliable model of HCV infection can better study in chronic HCV infection and carcinogenic mechanism be realized,thus to promote the development of hepatitis C vaccines and anti-HCV drugs.HCV has a particularly narrow host range,only humans and chimpanzees are susceptible to it.There are some in vivo and in vitro experiment results preliminarily showing that tupaia is currently the animal besides the chimpanzee which can be infected with HCV.Here is to make a review of the research progress in tupaia animal model of HCV infection.