CAJ | 학술논문

发动蛋白相关蛋白1(dynamin-related proteinl,Drpl)是调节线粒体分裂的主要蛋白,其活性与翻译后修饰有关,主要包括磷酸化、泛素化、类泛素化以及S-硝基化.在脑缺血时,Drp1被激活并从细胞质向线粒体外膜转位,介导线粒体分裂及受损线粒体的清除,在缺血神经元凋亡、坏死性凋亡、线粒体自噬等病理学过程中起重要作用.线粒体过度分裂或受损线粒体的积聚都会加重神经元损伤.
발동단백상관단백1(dynamin-related proteinl,Drpl)시조절선립체분렬적주요단백,기활성여번역후수식유관,주요포괄린산화、범소화、류범소화이급S-초기화.재뇌결혈시,Drp1피격활병종세포질향선립체외막전위,개도선립체분렬급수손선립체적청제,재결혈신경원조망、배사성조망、선립체자서등병이학과정중기중요작용.선립체과도분렬혹수손선립체적적취도회가중신경원손상.
Dynamin-related protein 1 (Drpl) is a major protein for regulating mitochondrial fission.Its activity is associated with the post-translational modification,mainly including phosphorylation,ubiquitination,sumoylation,and S-nitrosylation.During the cerebral ischemia,Drpl is activated and translocates from the cytoplasm to the mitochondrial outer membrane,mediates mitochondrial fission and eliminates damaged mitochondria.Drpl plays the important roles in the pathological processes of ischemic neuronal apoptosis,necrotic apoptosis,and mitophagy.Excessive mitochondria fission or accumulation of damaged mitochondria will aggravate neuronal injury.