CAJ | 학술논문

目的：探讨乙型肝炎及其肝硬化患者凝血功能动态检测的临床意义。方法收集182例乙肝患者（其中急性乙肝56例，慢性乙肝78例，肝硬化48例）和100例同期体检正常的对照者血浆进行检测。采用日本sysmex ca7000全自动血凝仪及配套试剂，检测：PT（血浆凝血酶原时间）、TT（凝血酶时间）、FIB（纤维蛋白原的含量）和APTT（活化部分凝血活酶时间）等指标。结果急性乙肝组与正常对照组相比，血浆PT、APTT、TT、FIB差异无显著性（P＞0．05），无统计学意义。而慢性乙肝、肝硬化组与正常对照组相比，血浆FIB含量有不同程度的减低（P＜0．05），其差异显著性有统计学意义，血浆PT、APTT、TT 测定值有不同程度的延长（P＜0．05），其差异显著性有统计学意义。结论乙肝患者凝血功能指标随其病情变化而发生异常改变，动态检测凝血功能指标有助于指导患者的诊断、治疗和预后判断。
목적：탐토을형간염급기간경화환자응혈공능동태검측적림상의의。방법수집182례을간환자（기중급성을간56례，만성을간78례，간경화48례）화100례동기체검정상적대조자혈장진행검측。채용일본sysmex ca7000전자동혈응의급배투시제，검측：PT（혈장응혈매원시간）、TT（응혈매시간）、FIB（섬유단백원적함량）화APTT（활화부분응혈활매시간）등지표。결과급성을간조여정상대조조상비，혈장PT、APTT、TT、FIB차이무현저성（P＞0．05），무통계학의의。이만성을간、간경화조여정상대조조상비，혈장FIB함량유불동정도적감저（P＜0．05），기차이현저성유통계학의의，혈장PT、APTT、TT 측정치유불동정도적연장（P＜0．05），기차이현저성유통계학의의。결론을간환자응혈공능지표수기병정변화이발생이상개변，동태검측응혈공능지표유조우지도환자적진단、치료화예후판단。
Objective To explore the clinical significance of dynamic detection of blood coagulation function in the patients with hepatitis B and cirrhosis of the liver. Methods The 182 cases of hepatitis B patients (78 cases of chronic hepatitis B,56 acute hepatitis B,cirrhosis in 48 cases) and 100 cases of in the same period normal physical body as control were collected their plasma for testing. Japanese sysmex ca7000 automatic blood coagulation instrument and auxiliary reagents were adopted for test:PT, (plasma prothrombin time),TT(thrombin time),FIB(content of fibrinogen) and APTT (activated clotting time live enzymes) and other indicators. Results Acute hepatitis B group compared with normal control group in the plasma PT,APTT,TT, FIB,there was no significant difference (P>0.05),no statistical significance. And chronic hepatitis B,liver cirrhosis group compared with normal control group,the plasma FIB content had the varying degree reduction (P<0.05),the significant differences had statistical significance;plasma PT,APTT,TT measurements had different levels of extended(P<0.05),the significant difference was statistically significant. Conclusion Blood coagulation function in patients with hepatitis B index changing with the illness and the abnormal change and dynamic detection of blood coagulation function indicators has help-guide to the patient's diagnosis ,treatment and prognosis judgement.