实用医药杂志
實用醫藥雜誌
실용의약잡지
Practical Journal of Medicine & Pharmacy
2015年
5期
409-411
,共3页
奈达铂%氟尿嘧啶%诱导化疗%同步放化疗%局部晚期鼻咽癌
奈達鉑%氟尿嘧啶%誘導化療%同步放化療%跼部晚期鼻嚥癌
내체박%불뇨밀정%유도화료%동보방화료%국부만기비인암
Nedaplatin%Fluorouracil%Induction chemotherapy%Concurrent chemoradiotherapy%Nasopharyngeal carcinoma
目的：观察并探讨奈达铂联合5氟尿嘧啶诱导化疗方案加同步放化疗治疗局部晚期鼻咽癌的近期疗效和不良反应。方法34例局部晚期鼻咽癌患者予以诱导化疗，方案为奈达铂80 mg／m2，d1；5氟尿嘧啶500 mg／m2，d1～5；21 d为1周期，2个周期后休息2周开始同步放化疗。同步化疗选择奈达铂80 mg／m2，d1，d22， d43；放疗采用常规放疗方案，鼻咽部剂量DT 68～70 Gy，2 Gy／次，5次／周。结果34例患者均完成治疗，无治疗相关性死亡。结束治疗后有效率达100％，其中CR 30例，PR 4例。不良反应在诱导化疗期间主要表现为白细胞减少（70．6％）在同步放化疗期间主要为血小板减少（52．9％）及口腔黏膜炎（100％）、放射性皮炎（100％）。结论奈达铂联合5氟尿嘧啶诱导化疗方案加同步放化疗治疗局部晚期鼻咽癌的近期疗效较好，不良反应可以耐受，远期疗效尚需进一步观察。
目的：觀察併探討奈達鉑聯閤5氟尿嘧啶誘導化療方案加同步放化療治療跼部晚期鼻嚥癌的近期療效和不良反應。方法34例跼部晚期鼻嚥癌患者予以誘導化療，方案為奈達鉑80 mg／m2，d1；5氟尿嘧啶500 mg／m2，d1～5；21 d為1週期，2箇週期後休息2週開始同步放化療。同步化療選擇奈達鉑80 mg／m2，d1，d22， d43；放療採用常規放療方案，鼻嚥部劑量DT 68～70 Gy，2 Gy／次，5次／週。結果34例患者均完成治療，無治療相關性死亡。結束治療後有效率達100％，其中CR 30例，PR 4例。不良反應在誘導化療期間主要錶現為白細胞減少（70．6％）在同步放化療期間主要為血小闆減少（52．9％）及口腔黏膜炎（100％）、放射性皮炎（100％）。結論奈達鉑聯閤5氟尿嘧啶誘導化療方案加同步放化療治療跼部晚期鼻嚥癌的近期療效較好，不良反應可以耐受，遠期療效尚需進一步觀察。
목적：관찰병탐토내체박연합5불뇨밀정유도화료방안가동보방화료치료국부만기비인암적근기료효화불량반응。방법34례국부만기비인암환자여이유도화료，방안위내체박80 mg／m2，d1；5불뇨밀정500 mg／m2，d1～5；21 d위1주기，2개주기후휴식2주개시동보방화료。동보화료선택내체박80 mg／m2，d1，d22， d43；방료채용상규방료방안，비인부제량DT 68～70 Gy，2 Gy／차，5차／주。결과34례환자균완성치료，무치료상관성사망。결속치료후유효솔체100％，기중CR 30례，PR 4례。불량반응재유도화료기간주요표현위백세포감소（70．6％）재동보방화료기간주요위혈소판감소（52．9％）급구강점막염（100％）、방사성피염（100％）。결론내체박연합5불뇨밀정유도화료방안가동보방화료치료국부만기비인암적근기료효교호，불량반응가이내수，원기료효상수진일보관찰。
Objective To evaluate the short-term effects and toxicity of nedaplatin combined 5-fluorouracil plus concurrent chemotherapy and radiotherapy for locally advanced nasopharyngeal carcinoma. Methods Total thirty -four patients with locally advanced nasopharyngeal carcinoma treated with 2 cycles of induction chemotherapy with nedaplatin (80 mg/m2,d1) and 5-fluorouracil (500 mg/m2,d1-d5) followed by 3 cycles of nedaplatin (80 mg/m2,d1,d22 and d43) and radiotherapy. The radiation technique was given with conventional radiotherapy;nasopharyngeal lesions were given a total amount of 68-74 Gy,2 Gy/f,5 fraction weekly. Results All 34 patients completed the planned dose therapy and there were no treatment-related deaths during the study. The overall response rates (CR+PR) were 100%. There was a high rate of neutropenia (70.6%) during induction chemotherapy. Over the concurrent chemotherapy treatment period,52.9%of patients had thrombocytopenia and 100% of patients had mucositis and skin desquamation. Conclusion Nedaplatin combined 5-fluorouracil plus concurrent chemotherapy and radiotherapy for locally advanced nasopharyngeal carcinoma is effective and tolerable,but long-term therapeutic effects of this treatment need futher observation.
