河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
11期
1926-1929
,共4页
恶性血液病%血流感染%病原菌特点%药物敏感性
噁性血液病%血流感染%病原菌特點%藥物敏感性
악성혈액병%혈류감염%병원균특점%약물민감성
Malignant blood disease%Blood infection%Pathogen features%Drug sensitivity
目的：探讨恶性血液病患者血流感染病原菌特点及药物敏感性，为临床合理用药提供可靠依据。方法：选取宣汉县人民医院2010年1月至2013年1月1268份恶性血液疾病患者血流感染的血培养标本，所有标本均进行菌种鉴定和药敏试验，统计病原菌分布情况及药物敏感性。结果：1268份血液培养标本中，检出94株病原菌，阳性率为7．41％；革兰阳性菌34株，占36．17％；革兰阴性菌55株，占58．51％；真菌5株，占5．32％；其中，以革兰阴性菌最为常见（ P＜0．01）；选择4种常见致病菌（人葡萄球菌、表皮葡萄球菌、肺炎克雷伯菌及大肠埃希菌）进行药敏试验，其中，革兰阳性菌对利福平及万古霉素最为敏感；革兰阴性菌对美洛培南、亚胺培南及丁胺卡那最为敏感。结论：恶性血液病患者血流感染发生率较高，病原菌主要为革兰阴性菌，且对多种抗菌药物均具有耐药性，临床治疗中应根据患者药敏试验结果合理选择抗菌药物。
目的：探討噁性血液病患者血流感染病原菌特點及藥物敏感性，為臨床閤理用藥提供可靠依據。方法：選取宣漢縣人民醫院2010年1月至2013年1月1268份噁性血液疾病患者血流感染的血培養標本，所有標本均進行菌種鑒定和藥敏試驗，統計病原菌分佈情況及藥物敏感性。結果：1268份血液培養標本中，檢齣94株病原菌，暘性率為7．41％；革蘭暘性菌34株，佔36．17％；革蘭陰性菌55株，佔58．51％；真菌5株，佔5．32％；其中，以革蘭陰性菌最為常見（ P＜0．01）；選擇4種常見緻病菌（人葡萄毬菌、錶皮葡萄毬菌、肺炎剋雷伯菌及大腸埃希菌）進行藥敏試驗，其中，革蘭暘性菌對利福平及萬古黴素最為敏感；革蘭陰性菌對美洛培南、亞胺培南及丁胺卡那最為敏感。結論：噁性血液病患者血流感染髮生率較高，病原菌主要為革蘭陰性菌，且對多種抗菌藥物均具有耐藥性，臨床治療中應根據患者藥敏試驗結果閤理選擇抗菌藥物。
목적：탐토악성혈액병환자혈류감염병원균특점급약물민감성，위림상합리용약제공가고의거。방법：선취선한현인민의원2010년1월지2013년1월1268빈악성혈액질병환자혈류감염적혈배양표본，소유표본균진행균충감정화약민시험，통계병원균분포정황급약물민감성。결과：1268빈혈액배양표본중，검출94주병원균，양성솔위7．41％；혁란양성균34주，점36．17％；혁란음성균55주，점58．51％；진균5주，점5．32％；기중，이혁란음성균최위상견（ P＜0．01）；선택4충상견치병균（인포도구균、표피포도구균、폐염극뢰백균급대장애희균）진행약민시험，기중，혁란양성균대리복평급만고매소최위민감；혁란음성균대미락배남、아알배남급정알잡나최위민감。결론：악성혈액병환자혈류감염발생솔교고，병원균주요위혁란음성균，차대다충항균약물균구유내약성，림상치료중응근거환자약민시험결과합리선택항균약물。
Objective:To investigate the characteristics of pathogenic bacteria infection and drug sensi-tivity of blood flow in patients with malignant blood diseases , and provide a reliable basis for clinical rational drug use.Method:Specimens were selected in Xuanhan People's Hospital in 2010 January -2013 years in January 1268 of malignant blood disease in patients with bloodstream infection blood culture;all the samples were subjected to strain identification and drug sensitivity test , the distribution of pathogens and drug sensi-tivity in statistics .Result:1268 copies of blood culture samples , 94 strains of bacteria were isolated .The positive rate was 7.41%;34 strains of gram positive bacteria , accounting for 36.17%;55 gram negative bac-teria, accounting for 58.51%; 5 strains of fungi, accounting for 5.32%; among them, the most common gram negative bacteria ( P<0.01 ); 4 kinds of common pathogenic bacteria ( Staphylococcus , epidermis Staphylococcus , Klebsiella pneumoniae and Escherichia coli ) drug sensitivity test , among them , gram posi-tive bacteria was the most sensitive to rifampicin and vancomycin; gram negative bacteria to meropenem , imipenem and amikacin was the most sensitive .Conclusion:The blood flow in patients with malignant blood diseases infection rate of pathogens are mainly gram negative bacteria , and for a variety of antibacterial drugs have resistance , should be a reasonable choice of antibiotics according to the drug sensitivity test results of patients in clinical treatment .
