中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
14期
47-50
,共4页
柯汝淑%陈雪华%赵小红%陈雅
柯汝淑%陳雪華%趙小紅%陳雅
가여숙%진설화%조소홍%진아
胎儿孕周%中期唐氏筛查%效率
胎兒孕週%中期唐氏篩查%效率
태인잉주%중기당씨사사%효솔
Fetus gestational weeks%Down's screening during the second trimester%Efficiency
目的:观察分析胎儿妊娠中期对唐氏综合征筛查效率的影响,为临床提供一定的参考数据。方法选取中期产前筛查的孕妇共36515例。根据孕周进行分组,共分为5组,分别为15孕周组(15~15+6)、16孕周组(16~16+6)、17孕周组(17~17+6),18孕周组(18~18+6)、19孕周组(19~20周)。对比不同孕周孕妇唐氏综合征患儿检出率和筛查假阳性率。结果孕周在15周组的孕妇有出现2例漏诊的病例,其中孕周在16周到18周的唐氏筛查检出率为100%。孕周在19周组孕妇没有确诊唐氏综合征患儿,因此假阳性率是7.85%。不同孕周段的筛查结果不同,其中孕周在16~18周的检出率为100%,筛查的假阳性率为4.36%。筛查阴性组孕妇AFP值随着孕周增加而增加,HCG值随着孕周增加而减少。筛查阳性组孕妇AFP均低于筛查阴性组,而HCG值则是比阴性组要高。结论唐氏综合征筛选在孕周期中期的16~18周进行检查,其筛查效果最高。
目的:觀察分析胎兒妊娠中期對唐氏綜閤徵篩查效率的影響,為臨床提供一定的參攷數據。方法選取中期產前篩查的孕婦共36515例。根據孕週進行分組,共分為5組,分彆為15孕週組(15~15+6)、16孕週組(16~16+6)、17孕週組(17~17+6),18孕週組(18~18+6)、19孕週組(19~20週)。對比不同孕週孕婦唐氏綜閤徵患兒檢齣率和篩查假暘性率。結果孕週在15週組的孕婦有齣現2例漏診的病例,其中孕週在16週到18週的唐氏篩查檢齣率為100%。孕週在19週組孕婦沒有確診唐氏綜閤徵患兒,因此假暘性率是7.85%。不同孕週段的篩查結果不同,其中孕週在16~18週的檢齣率為100%,篩查的假暘性率為4.36%。篩查陰性組孕婦AFP值隨著孕週增加而增加,HCG值隨著孕週增加而減少。篩查暘性組孕婦AFP均低于篩查陰性組,而HCG值則是比陰性組要高。結論唐氏綜閤徵篩選在孕週期中期的16~18週進行檢查,其篩查效果最高。
목적:관찰분석태인임신중기대당씨종합정사사효솔적영향,위림상제공일정적삼고수거。방법선취중기산전사사적잉부공36515례。근거잉주진행분조,공분위5조,분별위15잉주조(15~15+6)、16잉주조(16~16+6)、17잉주조(17~17+6),18잉주조(18~18+6)、19잉주조(19~20주)。대비불동잉주잉부당씨종합정환인검출솔화사사가양성솔。결과잉주재15주조적잉부유출현2례루진적병례,기중잉주재16주도18주적당씨사사검출솔위100%。잉주재19주조잉부몰유학진당씨종합정환인,인차가양성솔시7.85%。불동잉주단적사사결과불동,기중잉주재16~18주적검출솔위100%,사사적가양성솔위4.36%。사사음성조잉부AFP치수착잉주증가이증가,HCG치수착잉주증가이감소。사사양성조잉부AFP균저우사사음성조,이HCG치칙시비음성조요고。결론당씨종합정사선재잉주기중기적16~18주진행검사,기사사효과최고。
Objective To observe and analyze the effects of fetus gestational weeks on efficiency of Down's screening during the second trimester, and to provide certain reference data clinically. Methods A total of 36515 puerpera who received prenatal screening during the second trimester were selected. They were assigned to 5 groups according to their gestational weeks, which were group of 15 gestational weeks(15 to 16+6), group of 16 gestational weeks (16 to 16+6), group of 17 gestational weeks(17 to 17+6), group of 18 gestational weeks (18 to 18+6) and group of 19 ges-tational weeks (19 to 20 weeks). Detection rate and false screening positive rate of infants with Down's syndrome were compared between different gestation weeks. Results Two cases of missed diagnosis were seen in puerpera in the group of 15 gestation weeks. Detection rate of Down's screening in the group of 16 weeks to 18 weeks was 100%. No diagnosed infants with Down's syndrome were seen in the group of 19 gestational weeks. The false positive rate therefore was 7.85%. The screening results were different during different gestational weeks. Detection rate during 16 to 18 gestation weeks was 100%, and false positive rate of screening was 4.36%. In the negative groups of screened puerpera, AFP level increased with the increase of gestational weeks, and HCG level decreased with the increase of gestational weeks. In the positive groups of screened puerpera,their AFP levels were all lower than those in the nega-tive groups,and there HCG levels were higher than those in the negative groups. Conclusion Efficiency of screening is high when Down's screening during the second trimester of pregnancy is carried out during 16 to 18 gestational weeks.