中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
14期
17-20
,共4页
乳腺癌%血脂%载脂蛋白
乳腺癌%血脂%載脂蛋白
유선암%혈지%재지단백
Breast cancer%Serum lipid%Apolipoprotein
目的：探讨血脂及载脂蛋白与乳腺癌的相关性。方法取2012年3月~2014年3月在我院确诊为乳腺浸润性导管癌的82例患者及健康体检对照者80例的血清，分析血清总胆固醇（TC）、甘油三酯（TG）、载脂蛋白A（Apo-A）、载脂蛋白B（Apo-B）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平，并根据肿瘤的大小、淋巴结转移、组织分化程度等情况进行分组，比较各组的测定值。结果乳腺癌组TC、TG、LDL-C、Apo-B分别为（6.20±0.24）mmol/L、（2.45±0.12）mmol/L，（4.58±0.20）mmol/L、（1.25±0.15）g/L，对照组为（4.00±0.20）mmol/L、（0.67±0.17）mmol/L、（2.14±0.22）mmol/L、（0.86±0.24）g/L，乳腺癌组明显高于对照组，两组比较差异有统计学意义（P<0.05）；乳腺癌组 HDL-C、Apo-A分别为（0.90±0.11）mmol/L、（1.20±0.22）g/L，对照组为（1.98±0.21）mmol/L、（1.36±0.20）g/L，乳腺癌组低于对照组，两组比较差异有统计学意义（P<0.05）。大小≥2 cm组TC显著高于约2 cm组（P<0.05）。淋巴结转移者TC、TG、HDL-C、LDL-C、Apo-A、Apo-B与无转移者比较差异无统计学意义。乳腺癌低分化组血清TG水平高于高分化组，而高分化组血清HDL-C、Apo-A水平低于低分化组，差异有统计学意义（P<0.05）。结论 TC、TG、LDL-C、Apo-B异常升高，HDL-C、Apo-A的异常下降与乳腺癌的发生及恶变有相关性。
目的：探討血脂及載脂蛋白與乳腺癌的相關性。方法取2012年3月~2014年3月在我院確診為乳腺浸潤性導管癌的82例患者及健康體檢對照者80例的血清，分析血清總膽固醇（TC）、甘油三酯（TG）、載脂蛋白A（Apo-A）、載脂蛋白B（Apo-B）、高密度脂蛋白膽固醇（HDL-C）和低密度脂蛋白膽固醇（LDL-C）水平，併根據腫瘤的大小、淋巴結轉移、組織分化程度等情況進行分組，比較各組的測定值。結果乳腺癌組TC、TG、LDL-C、Apo-B分彆為（6.20±0.24）mmol/L、（2.45±0.12）mmol/L，（4.58±0.20）mmol/L、（1.25±0.15）g/L，對照組為（4.00±0.20）mmol/L、（0.67±0.17）mmol/L、（2.14±0.22）mmol/L、（0.86±0.24）g/L，乳腺癌組明顯高于對照組，兩組比較差異有統計學意義（P<0.05）；乳腺癌組 HDL-C、Apo-A分彆為（0.90±0.11）mmol/L、（1.20±0.22）g/L，對照組為（1.98±0.21）mmol/L、（1.36±0.20）g/L，乳腺癌組低于對照組，兩組比較差異有統計學意義（P<0.05）。大小≥2 cm組TC顯著高于約2 cm組（P<0.05）。淋巴結轉移者TC、TG、HDL-C、LDL-C、Apo-A、Apo-B與無轉移者比較差異無統計學意義。乳腺癌低分化組血清TG水平高于高分化組，而高分化組血清HDL-C、Apo-A水平低于低分化組，差異有統計學意義（P<0.05）。結論 TC、TG、LDL-C、Apo-B異常升高，HDL-C、Apo-A的異常下降與乳腺癌的髮生及噁變有相關性。
목적：탐토혈지급재지단백여유선암적상관성。방법취2012년3월~2014년3월재아원학진위유선침윤성도관암적82례환자급건강체검대조자80례적혈청，분석혈청총담고순（TC）、감유삼지（TG）、재지단백A（Apo-A）、재지단백B（Apo-B）、고밀도지단백담고순（HDL-C）화저밀도지단백담고순（LDL-C）수평，병근거종류적대소、림파결전이、조직분화정도등정황진행분조，비교각조적측정치。결과유선암조TC、TG、LDL-C、Apo-B분별위（6.20±0.24）mmol/L、（2.45±0.12）mmol/L，（4.58±0.20）mmol/L、（1.25±0.15）g/L，대조조위（4.00±0.20）mmol/L、（0.67±0.17）mmol/L、（2.14±0.22）mmol/L、（0.86±0.24）g/L，유선암조명현고우대조조，량조비교차이유통계학의의（P<0.05）；유선암조 HDL-C、Apo-A분별위（0.90±0.11）mmol/L、（1.20±0.22）g/L，대조조위（1.98±0.21）mmol/L、（1.36±0.20）g/L，유선암조저우대조조，량조비교차이유통계학의의（P<0.05）。대소≥2 cm조TC현저고우약2 cm조（P<0.05）。림파결전이자TC、TG、HDL-C、LDL-C、Apo-A、Apo-B여무전이자비교차이무통계학의의。유선암저분화조혈청TG수평고우고분화조，이고분화조혈청HDL-C、Apo-A수평저우저분화조，차이유통계학의의（P<0.05）。결론 TC、TG、LDL-C、Apo-B이상승고，HDL-C、Apo-A적이상하강여유선암적발생급악변유상관성。
Objective To investigate the correlation between serum lipids, apolipoprotein and breast cancer. Methods A survey on the prevalence of breast cancer was conducted in out hospital from March 2012 to March 2014. The data of 82 subjects with histologically confirmed breast cancer and 80 healthy control subjects were analyzed. Serum TC, TG, Apo-A, Apo-B, HDL-C, LDL-C were tested at the same time. The grouped according to tumor size, lymph node metastasis, the degree of tissue differentiation, measured values were compared. Results The levels of serum TC,TG, LDL-C, Apo-B in the breast cancer group were (6.20±0.24) mmol/L, (2.45±0.12) mmol/L, (4.58±0.20) mmol/L, (1.25±0.15)g/L respectively, while those in the control group were (4.00±0.20) mmol/L, (0.67±0.17) mmol/L, (2.14±0.22) mmol/L, (0.86±0.24) g/L respectively.All above parameters of the breast cancer group were significantly higher than those in the control group (P<0.05). The levels of serum HDL-C, Apo-A in the breast cancer group were (0.90±0.11) mmol/L and (1.20±0.22) g/L, and those in the control group were (1.98±0.21) mmol/L and (1.36±0.20) g/L, which was signifi-cantly lower than that of the control group (P<0.05). The serum TC level were significantly higher in the lump≥2 cm group than that of < 2 cm group (P<0.05). There was not significant difference between patients with lymph node metastasis and non-metastasis for the levels of serum TC, TG, HDL-C, LDL-C, Apo-A and Apo-B. The levels of serum TG in the breast cancer poorly differentiated group were higher than those in the well differentiated group (P<0.05). And in the well differentiated group, but the serum HDL-C, Apo-A were significantly lower than in poorly differentiated group, the differences were statistically significant (P<0.05). Conclusion Abnormal elevated of the serum TC, TG, LDL-C, Apo B and HDL-C, Apo-A decline is related to the tumors accruing and development of breast cancer.
