中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
15期
64-66,69
,共4页
瑞舒伐他汀%普罗布考%脑梗死%颈动脉粥样硬化斑块
瑞舒伐他汀%普囉佈攷%腦梗死%頸動脈粥樣硬化斑塊
서서벌타정%보라포고%뇌경사%경동맥죽양경화반괴
Rosuvastatin%Probucol%Infarction%Carotid atherosclerotic plaque
目的：探讨瑞舒伐他汀联合普罗布考对脑梗死患者颈动脉粥样硬化斑块的影响。方法选择脑梗死患者60例为研究对象，随机分为联合组和对照组各30例。联合组采用瑞舒伐他汀联合普罗布考治疗，对照组给予瑞舒伐他汀治疗。比较治疗前后两组患者颈动脉内膜厚度、斑块声学密度，检测两组患者治疗前后血脂、hs-CRP水平。结果两组治疗后TC、TG、LDL-C、hs-CRP水平较治疗前均显著下降，而HDL-C水平显著升高，差异有高度统计学意义（P<0.01）。治疗后，联合组血脂水平改善程度、hs-CRP下降程度均显著优于对照组（P<0.01）。两组治疗后颈动脉IMT厚度较治疗前均显著下降（P<0.01），联合组IMT厚度显著低于对照组；治疗后两组低回声斑块声学密度显著升高（P<0.01）；治疗后联合组高回声斑块声学密度显著升高（P<0.01），而对照组变化不明显；治疗后，联合组低回声斑块、高回声斑块声学密度均显著高于对照组（P<0.01）。结论脑梗死患者给予瑞舒伐他汀联合普罗布考治疗，能够显著改善血脂水平，稳定颈动脉粥样硬化斑块，抑制炎症反应。
目的：探討瑞舒伐他汀聯閤普囉佈攷對腦梗死患者頸動脈粥樣硬化斑塊的影響。方法選擇腦梗死患者60例為研究對象，隨機分為聯閤組和對照組各30例。聯閤組採用瑞舒伐他汀聯閤普囉佈攷治療，對照組給予瑞舒伐他汀治療。比較治療前後兩組患者頸動脈內膜厚度、斑塊聲學密度，檢測兩組患者治療前後血脂、hs-CRP水平。結果兩組治療後TC、TG、LDL-C、hs-CRP水平較治療前均顯著下降，而HDL-C水平顯著升高，差異有高度統計學意義（P<0.01）。治療後，聯閤組血脂水平改善程度、hs-CRP下降程度均顯著優于對照組（P<0.01）。兩組治療後頸動脈IMT厚度較治療前均顯著下降（P<0.01），聯閤組IMT厚度顯著低于對照組；治療後兩組低迴聲斑塊聲學密度顯著升高（P<0.01）；治療後聯閤組高迴聲斑塊聲學密度顯著升高（P<0.01），而對照組變化不明顯；治療後，聯閤組低迴聲斑塊、高迴聲斑塊聲學密度均顯著高于對照組（P<0.01）。結論腦梗死患者給予瑞舒伐他汀聯閤普囉佈攷治療，能夠顯著改善血脂水平，穩定頸動脈粥樣硬化斑塊，抑製炎癥反應。
목적：탐토서서벌타정연합보라포고대뇌경사환자경동맥죽양경화반괴적영향。방법선택뇌경사환자60례위연구대상，수궤분위연합조화대조조각30례。연합조채용서서벌타정연합보라포고치료，대조조급여서서벌타정치료。비교치료전후량조환자경동맥내막후도、반괴성학밀도，검측량조환자치료전후혈지、hs-CRP수평。결과량조치료후TC、TG、LDL-C、hs-CRP수평교치료전균현저하강，이HDL-C수평현저승고，차이유고도통계학의의（P<0.01）。치료후，연합조혈지수평개선정도、hs-CRP하강정도균현저우우대조조（P<0.01）。량조치료후경동맥IMT후도교치료전균현저하강（P<0.01），연합조IMT후도현저저우대조조；치료후량조저회성반괴성학밀도현저승고（P<0.01）；치료후연합조고회성반괴성학밀도현저승고（P<0.01），이대조조변화불명현；치료후，연합조저회성반괴、고회성반괴성학밀도균현저고우대조조（P<0.01）。결론뇌경사환자급여서서벌타정연합보라포고치료，능구현저개선혈지수평，은정경동맥죽양경화반괴，억제염증반응。
Objective To discuss effect of rosuvastatin combined with probucol on carotid atherosclerotic plaque for infarction. Methods Selected 60 cases with infarction were randomly divided into joint group (30 cases) and control group (30 cases). Joint group was treated with rosuvastatin and probucol, and control group was treated with rosuvastatin. IMT, plaque acoustic densitometry of two groups were compared, and lipid and hs-CRP levels were detected before and after treatment. Results TC, TG, LDL-C, hs-CRP of two groups after treatment were lower than before treatment, while HDL-C was higher (P<0.01). After treatment, TC, TG, LDL-C, hs-CRP of joint group were lower than control group, and HDL-C was higher than that in the control group (P<0.01). IMT of two groups after treatment were lower than that in the before treatment (P<0.01) and IMT of joint group was lower than that in the control group; Low density acoustic echo plaques of two groups after treatment were higher than before treatment (P<0.01); High densi ty acoustic echo plaques of joint group after treatment was higher than before treatment(P<0.01) while the control group was not obvi-ously; After treatment, acoustic echo plaques of jiont group were higher than control group (P<0.01). Conclusion Ro-suvastatin associated with probucol for infarction patients can significantly improve blood lipid levels, stabilize carotid atherosclerotic plaque, and inhibit inflammation effect.
