中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
15期
73-75
,共3页
2型糖尿病(T2DM)%门冬胰岛素%甘精胰岛素%临床疗效
2型糖尿病(T2DM)%門鼕胰島素%甘精胰島素%臨床療效
2형당뇨병(T2DM)%문동이도소%감정이도소%림상료효
Type 2 diabetes mellitus(T2DM)%Insulin aspart%Glargine%Clinical efficacy
目的：探讨门冬胰岛素联合甘精胰岛素治疗糖尿病的临床疗效。方法将60例2型糖尿病（T2DM）患者按照治疗方式分为对照组与观察组各30例，对照组采用人胰岛素注射液治疗，观察组采用门冬胰岛素联合甘精胰岛素治疗。比较两组治疗前后血糖水平、胰岛β细胞功能改善情况、胰岛素用量及血糖波动情况、治疗前后患者生活质量评分变化情况。结果①两组治疗后血糖指标（FBG、2hPBG及HbA1c）水平均显著低于治疗前（P<0.05），且观察组治疗后上述指标水平也均显著小于对照组（P<0.05）；②两组治疗后胰岛β细胞功能指标（FINS、2hINS、?I30/?G30及HOMAβ）水平均显著大于治疗前（P<0.05或P<0.01），且观察组治疗后上述指标水平也均显著大于对照组治疗后（P<0.05）；③观察组治疗后胰岛素用量及血糖波动值均显著小于对照组（P<0.05）。结论门冬胰岛素联合甘精胰岛素治疗糖尿病的临床疗效显著，可有效改善患者的血糖及胰岛β细胞功能，应在临床上对该方案进行推广。
目的：探討門鼕胰島素聯閤甘精胰島素治療糖尿病的臨床療效。方法將60例2型糖尿病（T2DM）患者按照治療方式分為對照組與觀察組各30例，對照組採用人胰島素註射液治療，觀察組採用門鼕胰島素聯閤甘精胰島素治療。比較兩組治療前後血糖水平、胰島β細胞功能改善情況、胰島素用量及血糖波動情況、治療前後患者生活質量評分變化情況。結果①兩組治療後血糖指標（FBG、2hPBG及HbA1c）水平均顯著低于治療前（P<0.05），且觀察組治療後上述指標水平也均顯著小于對照組（P<0.05）；②兩組治療後胰島β細胞功能指標（FINS、2hINS、?I30/?G30及HOMAβ）水平均顯著大于治療前（P<0.05或P<0.01），且觀察組治療後上述指標水平也均顯著大于對照組治療後（P<0.05）；③觀察組治療後胰島素用量及血糖波動值均顯著小于對照組（P<0.05）。結論門鼕胰島素聯閤甘精胰島素治療糖尿病的臨床療效顯著，可有效改善患者的血糖及胰島β細胞功能，應在臨床上對該方案進行推廣。
목적：탐토문동이도소연합감정이도소치료당뇨병적림상료효。방법장60례2형당뇨병（T2DM）환자안조치료방식분위대조조여관찰조각30례，대조조채용인이도소주사액치료，관찰조채용문동이도소연합감정이도소치료。비교량조치료전후혈당수평、이도β세포공능개선정황、이도소용량급혈당파동정황、치료전후환자생활질량평분변화정황。결과①량조치료후혈당지표（FBG、2hPBG급HbA1c）수평균현저저우치료전（P<0.05），차관찰조치료후상술지표수평야균현저소우대조조（P<0.05）；②량조치료후이도β세포공능지표（FINS、2hINS、?I30/?G30급HOMAβ）수평균현저대우치료전（P<0.05혹P<0.01），차관찰조치료후상술지표수평야균현저대우대조조치료후（P<0.05）；③관찰조치료후이도소용량급혈당파동치균현저소우대조조（P<0.05）。결론문동이도소연합감정이도소치료당뇨병적림상료효현저，가유효개선환자적혈당급이도β세포공능，응재림상상대해방안진행추엄。
Objective To investigate the clinical efficacy of insulin aspart insulin combined glargine in treatment of diabetes. Methods A total of 60 patients with type 2 diabetes mellitus (T2DM) patients according to treatment were randomly divided into the control group and the observation group, and the control group was given human insulin in-jection therapy, the observation group was given insulin aspart insulin combined with glargine. Blood glucose levels were compared before and after treatment, islet β cell function to improve the situation, the amount of insulin and blood sugar fluctuations, the quality of life in patients with scores before and after treatment were observed and com-pared. Results①After treatment,glycemic index (FBG, 2hPBG and HbA1c) levels were significantly lower than be-fore treatment (P<0.05), and the above target levels of the observation group after treatment were also significantly lower than those in the control group (P<0.05); ②After treatment, characterization of islet β cell function index (FINS,2hINS,?I30/?G30 and HOMAβ)were significantly higher than before treatment(P<0.05 or P<0.01), and the ob-servation group after treatment above target levels were also significantly higher than those in the control group (P<0.05); ③the dosage of insulin and blood sugar fluctuations in the observation group after treatment were significantly lower than those in the control group (P<0.05). Conclusion The clinical efficacy of winter insulin glargine combined treatment of diabetes significantly, which can effectively improve blood sugar and insulin in patients with β-cell func-tion and significantly improve the quality of life of patients,the program is worth clinical promotion.
