中国现代医生
中國現代醫生
중국현대의생
CHINA MODERN DOCTOR
2015年
15期
31-33,36
,共4页
子宫内膜息肉%左炔诺孕酮宫内系统%胰岛素样生长因子
子宮內膜息肉%左炔諾孕酮宮內繫統%胰島素樣生長因子
자궁내막식육%좌결낙잉동궁내계통%이도소양생장인자
Endometrial polyps%Levonorgestrel intrauterine system%Insulin-like growth factor-1
目的：研究左炔诺孕酮宫内释放系统对子宫内膜息肉患者子宫内膜组织胰岛素样生长因子-1（IGF-1）表达的影响。方法选取2010年1月~2011年12月期间行宫腔镜下子宫内膜息肉切除术182例患者为研究对象，将其随机分为对照组（常规治疗组）94例和研究组（宫内放置左炔诺孕酮宫内释放系统）88例。后通过免疫组化法将术中内膜组织及术后6个月子宫内膜活检IGF-1的表达情况进行对比，且追踪随访2年，观察患者子宫内膜息肉复发情况。结果研究组内膜组织IGF-1表达研究组术后明显低于术中，差异有统计学意义，对照组IGF-1的表达变化无差异性。随访2年对照组87例患者中7例子宫内膜息肉复发，复发率为8.05%，而研究组无一例复发，差异有统计学意义。结论左炔诺孕酮宫内释放系统可能通过抑制子宫内膜的IGF-1来降低子宫内膜息肉复发。
目的：研究左炔諾孕酮宮內釋放繫統對子宮內膜息肉患者子宮內膜組織胰島素樣生長因子-1（IGF-1）錶達的影響。方法選取2010年1月~2011年12月期間行宮腔鏡下子宮內膜息肉切除術182例患者為研究對象，將其隨機分為對照組（常規治療組）94例和研究組（宮內放置左炔諾孕酮宮內釋放繫統）88例。後通過免疫組化法將術中內膜組織及術後6箇月子宮內膜活檢IGF-1的錶達情況進行對比，且追蹤隨訪2年，觀察患者子宮內膜息肉複髮情況。結果研究組內膜組織IGF-1錶達研究組術後明顯低于術中，差異有統計學意義，對照組IGF-1的錶達變化無差異性。隨訪2年對照組87例患者中7例子宮內膜息肉複髮，複髮率為8.05%，而研究組無一例複髮，差異有統計學意義。結論左炔諾孕酮宮內釋放繫統可能通過抑製子宮內膜的IGF-1來降低子宮內膜息肉複髮。
목적：연구좌결낙잉동궁내석방계통대자궁내막식육환자자궁내막조직이도소양생장인자-1（IGF-1）표체적영향。방법선취2010년1월~2011년12월기간행궁강경하자궁내막식육절제술182례환자위연구대상，장기수궤분위대조조（상규치료조）94례화연구조（궁내방치좌결낙잉동궁내석방계통）88례。후통과면역조화법장술중내막조직급술후6개월자궁내막활검IGF-1적표체정황진행대비，차추종수방2년，관찰환자자궁내막식육복발정황。결과연구조내막조직IGF-1표체연구조술후명현저우술중，차이유통계학의의，대조조IGF-1적표체변화무차이성。수방2년대조조87례환자중7례자궁내막식육복발，복발솔위8.05%，이연구조무일례복발，차이유통계학의의。결론좌결낙잉동궁내석방계통가능통과억제자궁내막적IGF-1래강저자궁내막식육복발。
Objective To study levonorgestrel intrauterine system on insulin-like growth factor-1 (IGF-1) in endometri-um tissue for patients with endometrial polyps. Methods All 182 patients with endometrial polyps in our hospital from January 2010 to December 2011 were selected as research object, and randomly divided into control group(routine treatment group)94 cases and observation group(levonorgestrel intrauterine system in uterus group)88 cases. The IGF-1 expression of endometrial biopsy specimens during intraoperative and rechected after 6 months were measurd by im-munohistochemistry. Patients were followed up for 2 years to analyse endometrial polyp recurrence. Results The ex-pressions of IGF-1 decreased significant in endometrium tissue of observation group with operation. But there were no significant differences in control group. Followed up for 2 years, the endometrial polyp recurrence was 8.05% in control group and without recurrence in study group. Conclusion Levonorgestrel intrauterine system may be involved in the in-hibiting of the expression of IGF-1 then to induce the recurrence of endometrial polyps.
