CAJ | 학술논문

目的：探讨颈动脉粥样硬化与冠心病的相关性，分析与其相关的危险因素，为冠心病的早期诊断和治疗提供依据。方法：选取我院拟诊冠心病患者进行冠状动脉造影检查（ CAG），依据冠脉造影检查结果将拟诊冠心病患者分为冠心病组及对照组，对其进行颈动脉超声检查患者颈动脉内-中膜厚度（ IMT）及斑块积分（ Crouse），同时检测患者血清总胆固醇（ TC）、甘油三酯（ TG）、高密度脂蛋白胆固醇（ HDL-C）、低密度脂蛋白胆固醇（ LDL-C）以及血清同型半胱氨酸（ HCY）水平，所有结果均采用SPSS 16．0软件包进行统计学分析。结果：本次研究共收集了183例拟诊冠心病患者，其中冠心病组82例，对照组101例，经统计分析：冠心病组患者的IMT、Crouse积分均高于对照组（P＜0．05）；两组患者总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白固醇（LDL-C）水平相比无统计学意义（P＞0．05）；冠心病组患者的高密度脂蛋白胆固醇（HDL-C）水平低于对照组，有统计学意义（P＜0．05）；冠心病组的HCY水平高于对照组，差异有统计学意义（P＜0．01）。结论：颈动脉内-中膜厚度（IMT）及斑块形成与冠心病有着明显的相关性，HDL-C的降低和HCY的升高是动脉粥样硬化性疾病的危险因素。
목적：탐토경동맥죽양경화여관심병적상관성，분석여기상관적위험인소，위관심병적조기진단화치료제공의거。방법：선취아원의진관심병환자진행관상동맥조영검사（ CAG），의거관맥조영검사결과장의진관심병환자분위관심병조급대조조，대기진행경동맥초성검사환자경동맥내-중막후도（ IMT）급반괴적분（ Crouse），동시검측환자혈청총담고순（ TC）、감유삼지（ TG）、고밀도지단백담고순（ HDL-C）、저밀도지단백담고순（ LDL-C）이급혈청동형반광안산（ HCY）수평，소유결과균채용SPSS 16．0연건포진행통계학분석。결과：본차연구공수집료183례의진관심병환자，기중관심병조82례，대조조101례，경통계분석：관심병조환자적IMT、Crouse적분균고우대조조（P＜0．05）；량조환자총담고순（TC）、감유삼지（TG）、저밀도지단백고순（LDL-C）수평상비무통계학의의（P＞0．05）；관심병조환자적고밀도지단백담고순（HDL-C）수평저우대조조，유통계학의의（P＜0．05）；관심병조적HCY수평고우대조조，차이유통계학의의（P＜0．01）。결론：경동맥내-중막후도（IMT）급반괴형성여관심병유착명현적상관성，HDL-C적강저화HCY적승고시동맥죽양경화성질병적위험인소。
Objective:To investigate the correlation of carotid atherosclerosis with coronary heart disease(CHD) and the risk factors for evidence for early diagnosis and treatment of this conditions.Methods:Coronary arteriongraphy( CAG) was performed in suspected CHD patients,who were divided into CHD group and control group in compliance with CAG findings.Then two groups of patients were subjected to ultrasonic examination to measure the intima-media thickness(IMT) and estimate the plaque index by Crouse method,and were determined regarding levels of serum TG,TC,HDL-C,LDL-C and HCY.All results were computed with software SPSS,version 16.0.Results:A total of 183 suspected CHD cases were included,in which 82 were CHD,and 101 were controls.Statistics showed that IMT and Crouse scoring were higher in CHD group than those of the control group(P<0.05).The two groups were not significant concerning the levels of TC,TG and LDL-C(P>0.05),yet CHD patients had lower HDL-C level and higher HCY than the controls (P<0.05,P<0.01,respectively).Conclusion:IMT and plaque formation are significantly associated with CHD occurrence,and reduced HDL-C level yet elevated HCY are risk factors for atherosclerotic conditions .