皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2015年
3期
226-229
,共4页
曲普瑞林%人绒毛膜促性腺激素%触发排卵%卵泡未破黄素化综合征%卵巢过度刺激综合征
麯普瑞林%人絨毛膜促性腺激素%觸髮排卵%卵泡未破黃素化綜閤徵%卵巢過度刺激綜閤徵
곡보서림%인융모막촉성선격소%촉발배란%란포미파황소화종합정%란소과도자격종합정
triptorelin%human chorionic gonadotropin%ovulation induction%luteinized unruptured follicle syndrome%ovarian hyperstimulation syndrome
目的：观察绒毛膜促性腺激素（ HCG）、曲普瑞林与曲谱瑞林＋HCG应用于多囊卵巢综合征（ PCOS）患者卵泡成熟时“扳机”的临床效果比较。方法：138例PCOS患者均采用来曲唑＋尿促性腺激素（ HMG）诱导排卵，每组46例患者，分别使用HCG 10000 IU（A组）、曲普瑞林0．2 mg（B组）、曲谱瑞林0．1 mg＋HCG 5000 IU（C组），观察3组的排卵率、妊娠率及卵泡未破黄素化综合征（ LUFS）、卵巢过度刺激综合征（ OHSS）的发生情况。结果：本资料中显示3组排卵率和LUFS率有差异，A组的排卵率明显低于B、C组，LUFS率高于B、C组（P＜0．05）；3组临床妊娠率无统计学意义（P＞0．05）。结论：HCG组、曲普瑞林组与曲谱瑞林组＋HCG组均为帮助PCOS患者破卵的有效方法，但在PCOS患者中应用曲普瑞林则更加安全有效。
目的：觀察絨毛膜促性腺激素（ HCG）、麯普瑞林與麯譜瑞林＋HCG應用于多囊卵巢綜閤徵（ PCOS）患者卵泡成熟時“扳機”的臨床效果比較。方法：138例PCOS患者均採用來麯唑＋尿促性腺激素（ HMG）誘導排卵，每組46例患者，分彆使用HCG 10000 IU（A組）、麯普瑞林0．2 mg（B組）、麯譜瑞林0．1 mg＋HCG 5000 IU（C組），觀察3組的排卵率、妊娠率及卵泡未破黃素化綜閤徵（ LUFS）、卵巢過度刺激綜閤徵（ OHSS）的髮生情況。結果：本資料中顯示3組排卵率和LUFS率有差異，A組的排卵率明顯低于B、C組，LUFS率高于B、C組（P＜0．05）；3組臨床妊娠率無統計學意義（P＞0．05）。結論：HCG組、麯普瑞林組與麯譜瑞林組＋HCG組均為幫助PCOS患者破卵的有效方法，但在PCOS患者中應用麯普瑞林則更加安全有效。
목적：관찰융모막촉성선격소（ HCG）、곡보서림여곡보서림＋HCG응용우다낭란소종합정（ PCOS）환자란포성숙시“반궤”적림상효과비교。방법：138례PCOS환자균채용래곡서＋뇨촉성선격소（ HMG）유도배란，매조46례환자，분별사용HCG 10000 IU（A조）、곡보서림0．2 mg（B조）、곡보서림0．1 mg＋HCG 5000 IU（C조），관찰3조적배란솔、임신솔급란포미파황소화종합정（ LUFS）、란소과도자격종합정（ OHSS）적발생정황。결과：본자료중현시3조배란솔화LUFS솔유차이，A조적배란솔명현저우B、C조，LUFS솔고우B、C조（P＜0．05）；3조림상임신솔무통계학의의（P＞0．05）。결론：HCG조、곡보서림조여곡보서림조＋HCG조균위방조PCOS환자파란적유효방법，단재PCOS환자중응용곡보서림칙경가안전유효。
Objective:To compare the clinical efficacies of single dosage of human chorionic gonadotropin(HCG) or triptorelin and combined use of the two in triggering ovulation for patients with polycystic ovary syndrome ( PCOS) .Methods:A total of 138 PCOS patients were administered with letrozol and human menopausal gonadotropin(HMG) for ovulation induction,and allocated to three groups(n =46 for each).Once ovarian follicles matured,the pa-tients were treated with either HCG(10 000 IU,group A) or triptorelin (0.2 mg,group B) and combined triptorelin with HCG (0.1 mg+5 000 IU,group C) to trigger ovulation.Observed in the three groups were rates of ovulation and pregnancy as well as incidence of luteinized unruptured follicle syndrome (LUFS) and ovarian hyperstimulation syndrome (OHSS).Results:Generally,the ovulation rate and incidence of LUFS were different in the three groups. Group A had lower ovulation rate,yet higher incidence of LUFS than group B and C(P<0.05).However,the clinical pregnancy rate remained no signifi-cant differences in three groups (P>0.05).Conclusion:Although single dosage of HCG and triptorelin or combined use of the two can be effectively trig-ger ovulation in patiens with PCOS,triptorelin is safer in clinic.
