CAJ | 학술논문

目的：对比血管性帕金森综合征（ vascular Parkinson’ s syndrome，VP）与帕金森病（ Parkinson’ s disease，PD）临床特点及影像学特征。方法收集我院神经内科收治的70例VP患者作为VP组；同期来我院治疗的70例PD患者为PD组，记录并比较两组现病史（高血压病、冠心病、高脂血症、糖尿病、脑卒中），临床症状（静止性震颤、行走困难、步态不稳、偏侧躯体感觉障碍），以及头颅影像学改变。结果 VP组和PD组高血压病、冠心病、高脂血症、糖尿病、脑卒中发病率分别为（46％、52％、54％、40％、57％）、（30％、27％、28％、22％、38％），差异有统计学意义（P＜0．05）；PD组以静止性震颤为主，与VP组差异有统计学意义（P＜0．05），而VP组以行走困难、步态不稳为主要表现，与PD组比较，差异有统计学意义（P＜0．05）；VP组老年性脑改变数量、梗死灶数量明显多于PD组，差异有统计学意义（P＜0．05）。结论高血压病、冠心病、高脂血症、糖尿病、脑卒中为VP的危险因素，VP临床症状及影像学改变不同于PD。
목적：대비혈관성파금삼종합정（ vascular Parkinson’ s syndrome，VP）여파금삼병（ Parkinson’ s disease，PD）림상특점급영상학특정。방법수집아원신경내과수치적70례VP환자작위VP조；동기래아원치료적70례PD환자위PD조，기록병비교량조현병사（고혈압병、관심병、고지혈증、당뇨병、뇌졸중），림상증상（정지성진전、행주곤난、보태불은、편측구체감각장애），이급두로영상학개변。결과 VP조화PD조고혈압병、관심병、고지혈증、당뇨병、뇌졸중발병솔분별위（46％、52％、54％、40％、57％）、（30％、27％、28％、22％、38％），차이유통계학의의（P＜0．05）；PD조이정지성진전위주，여VP조차이유통계학의의（P＜0．05），이VP조이행주곤난、보태불은위주요표현，여PD조비교，차이유통계학의의（P＜0．05）；VP조노년성뇌개변수량、경사조수량명현다우PD조，차이유통계학의의（P＜0．05）。결론고혈압병、관심병、고지혈증、당뇨병、뇌졸중위VP적위험인소，VP림상증상급영상학개변불동우PD。
Objective To compare vascular Parkinson’ s syndrome and Parkinson’ s disease characterized by clinical features and imaging.Methods In department of Neurology in this hospital from December 2010 to August 2014 a total of 70 patients with VP were ascribed to VP group;in the same period in this hospital, 70 patients with Parkinson’ s disease were ascribed to Parkinson’ s dis-ease group (PD group) .(1) We recorded the two groups’ medical history (hypertension, coronary heart disease, high fat cholester-ol, diabetes, stroke) , clinical manifestations and symptoms ( resting tremor, difficulty in walking, unsteady gait, gait panic, lateral somatosensory disorders).(2) The changes in neuroimaging were observed.Results VP group and PD group had hypertension, coro-nary heart disease, high fat cholesterol, diabetes, stroke (46%、52%、54%、40%、57%,respectively) and (30%、27%、28%、22%、38%,respectively), the difference was statistically significant (P<0.05).The symptoms in Parkinson’s disease group were mainly resting tremor, the difference between PD and VP group was statistically significant ( P<0.05); and the main symptoms in VP pa-tients were difficulty in walking and unsteady gait , compared with the Parkinson’ s disease group, the difference was statistically signif-icant (P<0.05).In VP group, the number of senile brain changes and cerebral infarction were significantly more in number than in Parkinson’s disease group, the difference was statistically significant (P<0.05).Conclusions Hypertension, coronary heart dis-ease, high fat cholesterol, diabetes, and stroke, are risk factors for vascular Parkinson’ s syndrome.The clinical symptoms and ima-ging changes of VP are different from those of PD.