武警医学
武警醫學
무경의학
MEDICAL JOURNAL OF THE CHINESE PEOPLE'S ARMED POLICE FORCES
2015年
6期
576-579
,共4页
益生菌%重度急性胰腺炎%疗效%mete分析
益生菌%重度急性胰腺炎%療效%mete分析
익생균%중도급성이선염%료효%mete분석
probiotics%severe acute pancreatitis%efficacy%meta analysis
目的:用 Meta 分析的方法评价益生菌用于治疗重度急性胰腺炎( severe acute pancreatitis, SAP )的效果。方法检索PubMed、The Cochrane Library、中国生物医学文献数据库( CBM)、中文科技期刊数据库(维普),中国期刊全文数据库( CNKI),万方学术期刊全文数据库,全面查找益生菌治疗SAP的文献,评价纳入文献的方法学质量,用RevMan5.0软件统计分析。结果共纳入7篇文献,共有SAP患者654例,Meta分析结果显示实验组与对照组在病死率( RR=1.29,95% CI:0.77~2.16,P=0.33)、多器官衰竭发生率(RR=0.81,95%CI:0.52~1.24,P=0.33)、感染性并发症发生率(RR=0.72,95%CI:0.37~1.39,P=0.33)及抗生素使用率(RR=0.89,95%CI:0.71~1.10,P=0.28)方面均无统计学差异,但在胰腺脓肿发生率(RR=0.53,95%CI:0.28~0.98,P=0.04)方面存在统计学差异。结论益生菌不能降低SAP患者感染性并发症发生率、多器官衰竭发生率、抗生素使用率和病死率,但可能降低胰腺脓肿发生率。
目的:用 Meta 分析的方法評價益生菌用于治療重度急性胰腺炎( severe acute pancreatitis, SAP )的效果。方法檢索PubMed、The Cochrane Library、中國生物醫學文獻數據庫( CBM)、中文科技期刊數據庫(維普),中國期刊全文數據庫( CNKI),萬方學術期刊全文數據庫,全麵查找益生菌治療SAP的文獻,評價納入文獻的方法學質量,用RevMan5.0軟件統計分析。結果共納入7篇文獻,共有SAP患者654例,Meta分析結果顯示實驗組與對照組在病死率( RR=1.29,95% CI:0.77~2.16,P=0.33)、多器官衰竭髮生率(RR=0.81,95%CI:0.52~1.24,P=0.33)、感染性併髮癥髮生率(RR=0.72,95%CI:0.37~1.39,P=0.33)及抗生素使用率(RR=0.89,95%CI:0.71~1.10,P=0.28)方麵均無統計學差異,但在胰腺膿腫髮生率(RR=0.53,95%CI:0.28~0.98,P=0.04)方麵存在統計學差異。結論益生菌不能降低SAP患者感染性併髮癥髮生率、多器官衰竭髮生率、抗生素使用率和病死率,但可能降低胰腺膿腫髮生率。
목적:용 Meta 분석적방법평개익생균용우치료중도급성이선염( severe acute pancreatitis, SAP )적효과。방법검색PubMed、The Cochrane Library、중국생물의학문헌수거고( CBM)、중문과기기간수거고(유보),중국기간전문수거고( CNKI),만방학술기간전문수거고,전면사조익생균치료SAP적문헌,평개납입문헌적방법학질량,용RevMan5.0연건통계분석。결과공납입7편문헌,공유SAP환자654례,Meta분석결과현시실험조여대조조재병사솔( RR=1.29,95% CI:0.77~2.16,P=0.33)、다기관쇠갈발생솔(RR=0.81,95%CI:0.52~1.24,P=0.33)、감염성병발증발생솔(RR=0.72,95%CI:0.37~1.39,P=0.33)급항생소사용솔(RR=0.89,95%CI:0.71~1.10,P=0.28)방면균무통계학차이,단재이선농종발생솔(RR=0.53,95%CI:0.28~0.98,P=0.04)방면존재통계학차이。결론익생균불능강저SAP환자감염성병발증발생솔、다기관쇠갈발생솔、항생소사용솔화병사솔,단가능강저이선농종발생솔。
Objective To use method of the meta-analysis for evaluating efficacy of probiotics applied to severe acute pancrea-titis.Methods The PubMed, The Cochrane Library, CBM database, VIP database, CNKI database, and Wanfang database were searched, comprehensive literature search of the probiotics usage in the treatment of severe acute pancreatitis, and the methodological quality of literatures was evaluated.RevMan 5.0 software was used to conduct statistics and analysis.Results The study participants included 7 articles, a total of 654 patients with severe acute pancreatitis.There were no statistically significant differences in mortality (RR=1.29, 95%CI:0.77-2.16,P=0.33), multiple organ failure incidence (RR=0.81, 95%CI:0.52-1.24,P=0.33), infec-tious complications incidence(RR=0.72, 95%CI:0.37-1.39,P=0.33)and antibiotics usage(RR=0.89, 95% CI:0.71-1.10,P=0.28)between experimental group and control group.But there was significant statistical difference in pancreatic abscess incidence(RR=0.53, 95%CI:0.28-0.98,P=0.04).Conclusions According to the current research data, probiotics in SAP patients have no positive effects on mortality,multiple organ failure incidence, infectious complications incidence and antibiotics usage.But they can re-duce the incidence of pancreatic abscess.