CAJ | 학술논문

目的探讨北京地区健康人群N末端B型利钠肽原(NT-proBNP)的血浆水平及其影响因素.方法 2012年3至7月入选北京社区健康人群1 034例,其中男性486例,女性548例.留取血浆标本,采用荧光免疫分析法进行NT-proBNP检测.采用经验法估计NT-proBNP的正常参考值范围,分析影响健康人NT-proBNP血浆水平的因素.结果年龄和性别是影响健康人NT-proBNP水平的重要因素,年龄＜45岁、45 ～ 54岁、55 ～ 64岁、65 ～ 74岁时,男性NT-proBNP水平均明显低于女性(P值分别为0.005、0.001、0.001、0.011),年龄≥75岁时NT-proBNP水平性别间差异无统计学意义(P =0.504).无论男性、女性,NT-proBNP水平均随年龄增长而升高.体质指数也是影响NT-proBNP水平的独立因素(P＜0.001),而在一定肾功能范围内,估测肾小球滤过率并非NT-proBNP的独立影响因素.NT-proBNP参考值范围:＜55岁以下人群男性＜133 ng/L,女性＜289 ng/L;55～ 74岁人群男性＜ 185 ng/L,女性＜333 ng/L;≥75岁人群男性＜465 ng/L,女性＜378 ng/L.结论影响北京地区健康人血浆NT-proBNP水平的主要因素为年龄、性别和体质指数,根据这些因素探讨人群NT-proBNP参考值范围具有重要价值.
목적 탐토북경지구건강인군N말단B형리납태원(NT-proBNP)적혈장수평급기영향인소.방법 2012년3지7월입선북경사구건강인군1 034례,기중남성486례,녀성548례.류취혈장표본,채용형광면역분석법진행NT-proBNP검측.채용경험법고계NT-proBNP적정상삼고치범위,분석영향건강인NT-proBNP혈장수평적인소.결과 년령화성별시영향건강인NT-proBNP수평적중요인소,년령＜45세、45 ～ 54세、55 ～ 64세、65 ～ 74세시,남성NT-proBNP수평균명현저우녀성(P치분별위0.005、0.001、0.001、0.011),년령≥75세시NT-proBNP수평성별간차이무통계학의의(P =0.504).무론남성、녀성,NT-proBNP수평균수년령증장이승고.체질지수야시영향NT-proBNP수평적독립인소(P＜0.001),이재일정신공능범위내,고측신소구려과솔병비NT-proBNP적독립영향인소.NT-proBNP삼고치범위:＜55세이하인군남성＜133 ng/L,녀성＜289 ng/L;55～ 74세인군남성＜ 185 ng/L,녀성＜333 ng/L;≥75세인군남성＜465 ng/L,녀성＜378 ng/L.결론 영향북경지구건강인혈장NT-proBNP수평적주요인소위년령、성별화체질지수,근거저사인소탐토인군NT-proBNP삼고치범위구유중요개치.
Objective To investigate the plasma level of amino-terminal pro-brain natriuretic peptide (NT-proBNP) and related influencing factors in a community-based healthy population in Beijing area.Methods We measured plasma NT-proBNP level by fluoroimmunoassay between March 2012 and July 2012 from 1 034 healthy subjects (including 486 men and 548 women).Empiric method was used to determine the reference value and influencing factors were analyzed.Results Age and gender are important factors affecting the level of NT-proBNP in healthy subjects.NT-proBNP plasma level is significantly higher in women than in men within each age strata below 75 years old,i.e.＜45,45-54,55-64 and 65-74 years old (P =0.005,0.001,0.001,0.011 respectively),but NT-proBNP plasma level is similar between male and female older than 75 years (P =0.504).NT-proBNP level also increases with age irrespective of gender.Body mass index (BMI) is another independent influencing factor of NT-proBNP (P ＜0.001),while estimated glomerular filtration rate is not influencing factor.The reference range of NT-proBNP is ＜133 ng/L for men and ＜289 ng/L for women aged ＜55 years old,＜ 185 ng/L for men and ＜333 ng/L for women aged between 55 and 64 years old,and ＜465 ng/L for men and ＜378 ng/L for women aged ≥75 years old.Conclusion The major influencing factors of NT-proBNP level in the healthy population are age,gender and BMI.It essential to establish normal reference range of NT-proBNP according to these factors for Chinese population.