中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2015年
12期
21-22,23
,共3页
新癀片%急性痛风性关节炎%IL-1β%TNF-α
新癀片%急性痛風性關節炎%IL-1β%TNF-α
신황편%급성통풍성관절염%IL-1β%TNF-α
Xinhuang tablets%Acute gouty arthritis%Interleukin-1β%Tumor nec-rosis factor-α
目的：观察新癀片对急性痛风性关节炎患者血清白细胞介素1β（ IL－1β）和肿瘤坏死因子α（ TNF－α）的影响。方法：选择急性痛风性关节炎患者92例，随机分为新癀片治疗组和双氯芬酸钠喷雾剂治疗对照组。于治疗前、治疗3天、治疗7天后分别检测血清IL－1β和TNF－α含量。结果：观察组于新癀片治疗3天后血清IL－1β和TNF－α水平即明显降低（ P＜0．01），以后继续下降，与对照组比较差异有统计学意义（ P＜0．05）。结论：新癀片可降低急性痛风性关节炎患者血清IL－1β和TNF－α的水平，达到快速控制炎性反应的目的，可能是其治疗急性痛风性关节炎的机制之一。
目的：觀察新癀片對急性痛風性關節炎患者血清白細胞介素1β（ IL－1β）和腫瘤壞死因子α（ TNF－α）的影響。方法：選擇急性痛風性關節炎患者92例，隨機分為新癀片治療組和雙氯芬痠鈉噴霧劑治療對照組。于治療前、治療3天、治療7天後分彆檢測血清IL－1β和TNF－α含量。結果：觀察組于新癀片治療3天後血清IL－1β和TNF－α水平即明顯降低（ P＜0．01），以後繼續下降，與對照組比較差異有統計學意義（ P＜0．05）。結論：新癀片可降低急性痛風性關節炎患者血清IL－1β和TNF－α的水平，達到快速控製炎性反應的目的，可能是其治療急性痛風性關節炎的機製之一。
목적：관찰신황편대급성통풍성관절염환자혈청백세포개소1β（ IL－1β）화종류배사인자α（ TNF－α）적영향。방법：선택급성통풍성관절염환자92례，수궤분위신황편치료조화쌍록분산납분무제치료대조조。우치료전、치료3천、치료7천후분별검측혈청IL－1β화TNF－α함량。결과：관찰조우신황편치료3천후혈청IL－1β화TNF－α수평즉명현강저（ P＜0．01），이후계속하강，여대조조비교차이유통계학의의（ P＜0．05）。결론：신황편가강저급성통풍성관절염환자혈청IL－1β화TNF－α적수평，체도쾌속공제염성반응적목적，가능시기치료급성통풍성관절염적궤제지일。
Objective:To observe the effects of Xinhuang tablets on interleukin-1β( IL-1β) and tumor necrosis factor-α( TNF-α) in serum of patients with acute gouty arthritis.Methods:92 patients with acute gouty arthritis were randomly divided into Xinhuang tablets treatment group(46 cases) and diclofenac sodium spray treatment group(46 cases).The changes of IL-1βand TNF-αin serum of patients were observed before and after treatment.Results:After treatment, the average serum levels of IL-1βand TNF-αin Xin-huang tablets treatment group were descended significantly ,and there were significant differences found between these 2 patient groups. Conclusion:Xinhuang tablets may cure the disease and reduce the levels of IL-1βand TNF-αin patients with acute gouty arthritis, which might be looked as immune suppression effects.
