CAJ | 학술논문

目的：观察通心络胶囊治疗老年冠心病经皮冠状动脉介入治疗（ PCI）术后心绞痛的临床疗效。方法将老年冠心病 PCI 术后心绞痛患者116例随机分为2组，对照组56例予阿司匹林、氯吡格雷、单硝酸异山梨酯、酒石酸美托洛尔、阿托伐他汀钙等常规治疗，治疗组60例在对照组基础上加用通心络胶囊。2组治疗时间均为6个月，比较治疗前后心绞痛症状疗效、心电图疗效，测定超敏－C 反应蛋白（hs －CRP）、一氧化氮（NO）、内皮素－1（ET －1）及血脂指标水平变化。结果治疗组治疗后心绞痛症状疗效、心电图疗效优于对照组（P ＜0．05）；治疗后2组血浆 NO 水平升高（P ＜0．05），ET －1、hs －CRP 水平降低（P ＜0．05），且2组组间比较差异有统计学意义（P ＜0．05）。2组治疗后总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL －C）水平均较本组治疗前下降（P ＜0．05），且治疗组 TC、LDL －C 较对照组下降明显（P ＜0．05）。结论通心络胶囊可显著减少老年冠心病 PCI 术后心绞痛发作频率，同时改善患者心电图 ST －T 变化，调整血脂，升高血浆 NO 水平，降低 ET －1、hs －CRP 水平，是辅助治疗冠心病 PCI 术后心绞痛的一种安全有效的方法。
목적：관찰통심락효낭치료노년관심병경피관상동맥개입치료（ PCI）술후심교통적림상료효。방법장노년관심병 PCI 술후심교통환자116례수궤분위2조，대조조56례여아사필림、록필격뢰、단초산이산리지、주석산미탁락이、아탁벌타정개등상규치료，치료조60례재대조조기출상가용통심락효낭。2조치료시간균위6개월，비교치료전후심교통증상료효、심전도료효，측정초민－C 반응단백（hs －CRP）、일양화담（NO）、내피소－1（ET －1）급혈지지표수평변화。결과치료조치료후심교통증상료효、심전도료효우우대조조（P ＜0．05）；치료후2조혈장 NO 수평승고（P ＜0．05），ET －1、hs －CRP 수평강저（P ＜0．05），차2조조간비교차이유통계학의의（P ＜0．05）。2조치료후총담고순（TC）、감유삼지（TG）、저밀도지단백담고순（LDL －C）수평균교본조치료전하강（P ＜0．05），차치료조 TC、LDL －C 교대조조하강명현（P ＜0．05）。결론통심락효낭가현저감소노년관심병 PCI 술후심교통발작빈솔，동시개선환자심전도 ST －T 변화，조정혈지，승고혈장 NO 수평，강저 ET －1、hs －CRP 수평，시보조치료관심병 PCI 술후심교통적일충안전유효적방법。
Objective To observe the clinical effects of Tongxinluo capsule on angina in aged patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI).Methods 116 aged patients with coronary heart disease after percutaneous coronary intervention were randomly divided into two groups .56 pa-tients in control group were treated by routine therapy such as aspirin ,clopidogrel,isosorbide mononitrate,metoprolol tartrate and atorvastatin calcium tablets .Patients in treatment group were treated by Tongxinluo capsule on the basis of control group treatment.The course was six months in two groups .The changes of symptoms of angina ,ECG effica-cy,the levels of high -sensitive c -reactive protein (hs -CRP),nitric oxide (NO),endothelin -1 (EP -1) and blood lipid indices were compared between before and after treatment in two groups .Results The curative effects of angina and ECG after treatment in treatment group were superior to those in control group (P <0.05).The level of serum NO after treatment was increased (P <0.05),the levels of ET -1 and hs -CRP were decreased (P <0.05), and there were significant differences between two groups (P <0.05).The levels of total cholesterol (TC),triglycer-ide (TG) and low density lipoprotein (LDL -C) after treatment were decreased (P <0.05),and the decreased of TC,LDL -C in treatment group was more obvious than that in control group (P <0.05).Conclusion Tongxinluo capsule can significantly reduce the occurrence frequency of angina in aged patients with coronary heart disease after percutaneous coronary intervention ,and improve st -t changes of ECG,regulate blood lipids,increase the serum NO level and decrease the level of ET -1 and hs -CRP,is a safe and effective adjuvant therapy .