CAJ | 학술논문

目的：研究临床Ⅲ期及Ⅳa 期初治鼻咽癌患者调强放疗联合化疗的临床疗效及急慢性不良反应。方法：对40例Ⅲ期、IVa 期初治鼻咽癌患者行调强放疗，配合以铂类为基础的全身化疗。结果：早期不良反应多为1、2级放射性口腔黏膜炎（85%）和1、2级皮肤放射反应（87.5%），患者可耐受。晚期不良反应为口干为主，随着治疗后时间的延长，口干症状逐渐减轻。中位随访时间为40个月，1、3总生存率为95%，85.9%。1、3年局部区域控制率97.4%，91.6%。1、3无远处转移生存率97.4%，81.5%。结论：调强放疗联合铂类化疗使得Ⅲ期及Ⅳa 期鼻咽癌患者的局部区域控制率和总生存率得到了提高，局部区域控制率提高最为显著，不良反应可以耐受，生活质量得到明显的改善。
목적：연구림상Ⅲ기급Ⅳa 기초치비인암환자조강방료연합화료적림상료효급급만성불량반응。방법：대40례Ⅲ기、IVa 기초치비인암환자행조강방료，배합이박류위기출적전신화료。결과：조기불량반응다위1、2급방사성구강점막염（85%）화1、2급피부방사반응（87.5%），환자가내수。만기불량반응위구간위주，수착치료후시간적연장，구간증상축점감경。중위수방시간위40개월，1、3총생존솔위95%，85.9%。1、3년국부구역공제솔97.4%，91.6%。1、3무원처전이생존솔97.4%，81.5%。결론：조강방료연합박류화료사득Ⅲ기급Ⅳa 기비인암환자적국부구역공제솔화총생존솔득도료제고，국부구역공제솔제고최위현저，불량반응가이내수，생활질량득도명현적개선。
Purpose To study the clinical efficiency and the acute and late normal tissue toxicities of Stage Ⅲ and stageⅣa untreated nasopharyngeal carcinoma patients treated by intensity modulated radiation therapy (IMRT) with chemotherapy. Methods A total of 40 patients untreated NPC patients received IMRT with platinum-based chemotherapy. Results The incidences of acute grade 1 and grade 2 toxicity of mucous and skin were 85%, 87.5%, respectively and the acute toxicities were tolerable.The main late toxicity was xerostomia decreased with time going. The median follow-up interval was 40 month (3-80months). The 1-year and 3-years overall survival rate were 95%, 85.9%. The local-regional control rates were 97.4%, 91.6%. and the l-year and 3-year disease metastasis-free were 97.4%, 81.5%, respectively. Conclusions IMRT combined platinum-based chemotherapy was an effective treatment and could get good overall survival and local-regional free survival for Stage Ⅲand stage Ⅳa untreated nasopharyngeal carcinoma (NPC)patients. The toxicities were slight and tolerable.