CAJ | 학술논문

目的：对蒽环类耐药晚期乳腺癌患者采用盖诺联合顺铂化疗治疗，观察和分析其临床疗效。方法：选取本院2006年6月～2009年6月期间收治的144例晚期乳腺癌患者进行研究。按照随机数字表法将其分组为对照组和治疗组。对照组采用多西他赛联合顺铂治疗；治疗组采用盖诺联合顺铂治疗。比较两组患者5年生存率、生活质量、近期疗效、不良反应。结果：治疗组5年生存率分别38.89%(28/72)与对照组27.78%(20/72)比较。治疗组生活质量评分和不良反应率及近期疗效与对照组比较。结论：相比多西他赛来说，临床采用盖诺联合顺铂治疗蒽环类耐药晚期乳腺癌患者，提高治疗效果。同时治疗期间所发生不良反应少，提高患者耐受性，促进治疗顺利进行，提高患者生活质量。
목적：대은배류내약만기유선암환자채용개낙연합순박화료치료，관찰화분석기림상료효。방법：선취본원2006년6월～2009년6월기간수치적144례만기유선암환자진행연구。안조수궤수자표법장기분조위대조조화치료조。대조조채용다서타새연합순박치료；치료조채용개낙연합순박치료。비교량조환자5년생존솔、생활질량、근기료효、불량반응。결과：치료조5년생존솔분별38.89%(28/72)여대조조27.78%(20/72)비교。치료조생활질량평분화불량반응솔급근기료효여대조조비교。결론：상비다서타새래설，림상채용개낙연합순박치료은배류내약만기유선암환자，제고치료효과。동시치료기간소발생불량반응소，제고환자내수성，촉진치료순리진행，제고환자생활질량。
Objective Anthracycline-resistant advanced breast cancer chemotherapy treatment vinorelbine plus cispla-tin, observation and analysis of its clinical efficacy. Methods Select the hospital in June 2006 and June 2009 were treated 144 patients with advanced breast cancer research. According to a random number table to be grouped into a control group and thetreatment group. The control group received docetaxel plus cisplatin treatment; treatment group with vinorelbine plus cisplatin therapy. 5-year survival rate between the two groups of patients, quality of life, short-term efficacy, adverse reactions. Results 5-year survival rate of the treatment group were 38.89% (28/72) in the control group and 27.78% (20/72) comparison. Quality of life in the treatment group scores and adverse reaction rates and short-term efficacy compared with control group. Conclusions Compared to docetaxel, the clinical use of vinorelbine and cisplatin in the treatment of anthracycline-resistant advanced breast cancer patients, improve the therapeutic effect. While fewer adverse reactions that occurred during treatment, improve patient tolerance, and promote the smooth conduct of treatment and improve the quality of life of patients.