CAJ | 학술논문

目的评价牙周病与子痫前期的关系,以及牙周病的治疗对子痫前期的影响. 方法检索中国期刊全文数据库、中国生物医学文献数据库、万方数字化期刊全文数据库、中国学位论文全文数据库和中国重要会议论文全文数据库以及Cochrane Library、PubMed、EMbase、Elsevier、Springer、Science Direct OnSite外文数据库,检索时限从各数据库建库至2014年9月30日,收集有关牙周病与子痫前期关系的病例对照研究、队列研究和随机对照试验.按纳入与排除标准筛选文献、评价质量、提取数据.采用RevMan5.1软件及Stata12.0软件对纳入的研究进行meta分析,根据异质性结果选择相应的效应模型分析. 结果共纳入20项(15项病例对照研究,5项队列研究,n=8 775)关于牙周病与子痫前期关系的研究,以及4项(n=3 712)牙周病治疗对子痫前期影响的随机对照试验.Meta分析显示,牙周病与子痫前期呈正相关(OR=2.48,95％CI:1.76～3.48,P＜0.01).按研究类型进行亚组分析,病例对照研究结果显示牙周病可能是子痫前期发病的危险因素(OR=2.75,95％CI:1.93～3.92,P＜0.01),而队列研究结果显示牙周病与子痫前期的关系差异无统计学意义(OR=1.84,95％CI:0.91～3.74,P＞0.05).随机对照试验的meta分析结果显示,牙周病的治疗并不影响子痫前期的发生与病情进展(RR=1.04,95％CI:0.84～1.30,P＞0.05). 结论牙周病可能是子痫前期发病的危险因素,但牙周病治疗与否对子痫前期的发生及进展无明显影响.鉴于本研究的局限之处,期待高质量前瞻性研究进一步明确二者的关系.
목적 평개아주병여자간전기적관계,이급아주병적치료대자간전기적영향. 방법 검색중국기간전문수거고、중국생물의학문헌수거고、만방수자화기간전문수거고、중국학위논문전문수거고화중국중요회의논문전문수거고이급Cochrane Library、PubMed、EMbase、Elsevier、Springer、Science Direct OnSite외문수거고,검색시한종각수거고건고지2014년9월30일,수집유관아주병여자간전기관계적병례대조연구、대렬연구화수궤대조시험.안납입여배제표준사선문헌、평개질량、제취수거.채용RevMan5.1연건급Stata12.0연건대납입적연구진행meta분석,근거이질성결과선택상응적효응모형분석. 결과 공납입20항(15항병례대조연구,5항대렬연구,n=8 775)관우아주병여자간전기관계적연구,이급4항(n=3 712)아주병치료대자간전기영향적수궤대조시험.Meta분석현시,아주병여자간전기정정상관(OR=2.48,95％CI:1.76～3.48,P＜0.01).안연구류형진행아조분석,병례대조연구결과현시아주병가능시자간전기발병적위험인소(OR=2.75,95％CI:1.93～3.92,P＜0.01),이대렬연구결과현시아주병여자간전기적관계차이무통계학의의(OR=1.84,95％CI:0.91～3.74,P＞0.05).수궤대조시험적meta분석결과현시,아주병적치료병불영향자간전기적발생여병정진전(RR=1.04,95％CI:0.84～1.30,P＞0.05). 결론 아주병가능시자간전기발병적위험인소,단아주병치료여부대자간전기적발생급진전무명현영향.감우본연구적국한지처,기대고질량전첨성연구진일보명학이자적관계.
Objective To explore the relationship between periodontal disease and preeclampsia and the effects of periodontal treatment on preeclampsia.Methods China National Knowledge Infrastructure,Chinese Biomedical Literature Database,WANGFANG DATA,China Dissertation Full-Text Database,China Proceedings of Conference Full-Text Database,Cochrane Library,PubMed,EMbase,Elsevier,Springer,and Science Direct OnSite were extracted from inception till September 30,2014.The case-control,cohort and randomized controlled trials about the association of matemal periodontal disease and preeclampsia were searched according to the inclusion and exclusion criteria.RevMan5.1 and Stata12.0 were used to test the heterogeneity of the results among the different studies and amalgamate the effect size using fixed or random effect models.Results Twenty studies (15 case-control and 5 cohort) involving 8 775 women assessed the association between periodontal disease and preeclampsia.A positive association was found (OR=2.48,95％CI:1.76-3.48,P ＜ 0.01).Meta-analysis of the case-control studies showed more than twice in the odds of preeclampsia with the presence of periodontal disease (OR=2.75,95％CI:1.93-3.92,P ＜ 0.01).Meta-analysis of cohort studies did not reveal any significant differences (OR=1.84,95％CI:0.91-3.74,P ＞ 0.05).Four randomized controlled trials with 3 712 women evaluated the effect of periodontal treatment on preeclampsia,and meta-analysis showed no relative risk reduction in preeclampsia with periodontal treatment (RR=1.04,95％CI:0.84-1.30,P ＞ 0.05).Conclusions Periodontal disease appears to be a possible risk factor for preeclampsia,but treatment during pregnancy does not prevent preeclampsia.High-quality prospective studies are needed to confirm the relationship between periodontal disease and preeclampsia.