CAJ | 학술논문

目的：：比较哌拉西林钠他唑巴坦钠联用阿奇霉素(A组)和头孢他啶联用阿奇霉素(B组)两种方案治疗社区获得性肺炎( CAP)的费用与疗效。方法：采用回顾性调查方法，收集渝北区人民医院2014年1月至12月住院治疗CAP患者资料，筛选出A组和B组治疗方案患者资料。统计分析两种治疗方案的疗效、药品费用和不良反应，并计算成本-效果比(C/E)。结果：两种治疗方案临床有效率无显著差异(P>0.05)；两组患者体温、咳嗽、肺部啰音、X线胸片、白细胞计数、中性粒细胞比例、细菌清除率等疗效指标无显著差异(P>0.05)；两组患者不良反应发生率无显著差异(P>0.05)；B组C/E值显著低于A组C/E值(P<0.05)。结论：哌拉西林钠他唑巴坦钠联用阿奇霉素与头孢他啶联用阿奇霉素两种方案用于我院CAP安全性和有效性相同，但后者具有更好的经济性。
목적：：비교고랍서림납타서파탄납련용아기매소(A조)화두포타정련용아기매소(B조)량충방안치료사구획득성폐염( CAP)적비용여료효。방법：채용회고성조사방법，수집투북구인민의원2014년1월지12월주원치료CAP환자자료，사선출A조화B조치료방안환자자료。통계분석량충치료방안적료효、약품비용화불량반응，병계산성본-효과비(C/E)。결과：량충치료방안림상유효솔무현저차이(P>0.05)；량조환자체온、해수、폐부라음、X선흉편、백세포계수、중성립세포비례、세균청제솔등료효지표무현저차이(P>0.05)；량조환자불량반응발생솔무현저차이(P>0.05)；B조C/E치현저저우A조C/E치(P<0.05)。결론：고랍서림납타서파탄납련용아기매소여두포타정련용아기매소량충방안용우아원CAP안전성화유효성상동，단후자구유경호적경제성。
Objective:To compare the cost and efficacy between piperacillin sodium/tazobactam sodium combined with azithro-mycin (group A) and ceftazidime combined with azithromycin (group B) in treatment of community acquired pneumonia (CAP). Methods:Retrospective survey methodology was used to collect the clinical data of CAP inpatients who belonged to group A or group B in People’s Hospital of Yubei District of Chongqing City from January 2014 to December 2014. The therapeutic effect,adverse effect and drug cost were analyzed,and the cost-efficacy ( C/E) was calculated. Results:There was no difference in effective rate,body tem-perature,cough,lung rales,chest X-ray,white blood cell count,neutrophil rate and bacterial clearance rate between group A and group B (P>0. 05). C/E of group B was lower than that of group A (P<0. 05). Conclusion:Efficacy and safety of piperacillin sodium/tazobactam sodium combined with azithromycin is same to ceftazidime combined with azithromycin in treatment of CAP in our hospital, but the latter is more economic.