湖南师范大学学报（医学版）
湖南師範大學學報（醫學版）
호남사범대학학보（의학판）
JOURNAL OF HUNAN NORMAL UNIVERSITY(MEDICAL SCIENCE)
2015年
2期
31-34
,共4页
血清前白蛋白%视黄醇结合蛋白%脓毒血症%早期肝功能损害
血清前白蛋白%視黃醇結閤蛋白%膿毒血癥%早期肝功能損害
혈청전백단백%시황순결합단백%농독혈증%조기간공능손해
prealbumin%retinol-binding protein%sepsis%the early damage of liver function
目的：探讨血清前白蛋白(PA)与视黄醇结合蛋白(RBP)在儿童脓毒血症肝、肾功能早期损伤中的临床意义。方法：收集湖南省人民医院儿童医学中心呼吸病房2014年2~10月住院的脓毒血症患儿100例，完全符合入组标准者90例。非脓毒血症患儿100例，符合入组标准者98例，取同期正常体检儿童80例为正常对照组，分别收集三组相关临床资料，采用日立7600全自动生化分析仪检测肝肾功能及 PA 与 RBP 水平，并进行统计学分析。结果：脓毒血症组 PA、RBP 含量均明显低于非脓毒血症组和正常对照组，差异有统计学意义；非脓毒血症组 PA 及 RBP 水平较正常组均稍低，但差异无明显统计学意义。与非脓毒血症组与正常对照组相比，脓毒血症组WBC 计数、中性粒细胞百分比、CRP、血糖、谷丙转氨酶增高、血清白蛋白(ALB)降低，差异均有统计学意义，肌酐、尿素氮、总胆红素、直接胆红素等均无明显统计学差异。结论：PA 及 RBP 水平的变化是早期肝、肾功能损害的因子，血清 PA 与 RBP 下降有利于发现脓毒血症患儿早期脏器损伤。
目的：探討血清前白蛋白(PA)與視黃醇結閤蛋白(RBP)在兒童膿毒血癥肝、腎功能早期損傷中的臨床意義。方法：收集湖南省人民醫院兒童醫學中心呼吸病房2014年2~10月住院的膿毒血癥患兒100例，完全符閤入組標準者90例。非膿毒血癥患兒100例，符閤入組標準者98例，取同期正常體檢兒童80例為正常對照組，分彆收集三組相關臨床資料，採用日立7600全自動生化分析儀檢測肝腎功能及 PA 與 RBP 水平，併進行統計學分析。結果：膿毒血癥組 PA、RBP 含量均明顯低于非膿毒血癥組和正常對照組，差異有統計學意義；非膿毒血癥組 PA 及 RBP 水平較正常組均稍低，但差異無明顯統計學意義。與非膿毒血癥組與正常對照組相比，膿毒血癥組WBC 計數、中性粒細胞百分比、CRP、血糖、穀丙轉氨酶增高、血清白蛋白(ALB)降低，差異均有統計學意義，肌酐、尿素氮、總膽紅素、直接膽紅素等均無明顯統計學差異。結論：PA 及 RBP 水平的變化是早期肝、腎功能損害的因子，血清 PA 與 RBP 下降有利于髮現膿毒血癥患兒早期髒器損傷。
목적：탐토혈청전백단백(PA)여시황순결합단백(RBP)재인동농독혈증간、신공능조기손상중적림상의의。방법：수집호남성인민의원인동의학중심호흡병방2014년2~10월주원적농독혈증환인100례，완전부합입조표준자90례。비농독혈증환인100례，부합입조표준자98례，취동기정상체검인동80례위정상대조조，분별수집삼조상관림상자료，채용일립7600전자동생화분석의검측간신공능급 PA 여 RBP 수평，병진행통계학분석。결과：농독혈증조 PA、RBP 함량균명현저우비농독혈증조화정상대조조，차이유통계학의의；비농독혈증조 PA 급 RBP 수평교정상조균초저，단차이무명현통계학의의。여비농독혈증조여정상대조조상비，농독혈증조WBC 계수、중성립세포백분비、CRP、혈당、곡병전안매증고、혈청백단백(ALB)강저，차이균유통계학의의，기항、뇨소담、총담홍소、직접담홍소등균무명현통계학차이。결론：PA 급 RBP 수평적변화시조기간、신공능손해적인자，혈청 PA 여 RBP 하강유리우발현농독혈증환인조기장기손상。
Objective To discuss whether prealbumin (PA)and retinol-binding protein(RBP) in early stage of liver and renal injury were significative to sepsis in children. Methods 100 sepsis patients were enrolled from the respiratory ward of Children’ s Medical Center in Hunan Provincial People’s Hospital from February 2014 to October 2014,and among them above 90 cases were full compliance with the standard.98 cases were full compliance with the standard in 100 cases with non-sepsis. Took 80 healthy children in the same period by physical examination as normal control group. Measured the concentrations of the liver function, renal function, PA and RBP using Hitachi 7600 automatic biochemical analyzer .Collected relevant clinical data of the three groups for statistical analysis at the same time. Results The levels of PA and RBP in Sepsis group were significantly lower than non-sepsis group and the normal group.The levels of PA and RBP in the Non-sepsis group were slightly lower than the nor-mal group, but the difference was not statistically significant.In sepsis group ,the levels of WBC count, N%, CRP, BS, ALT were higher than non-sepsis group and the normal group, and ALB in sepsis group were lower than other two groups,and the differ-ences of them were all statistically significant.There were no significant statistical differences, in other indicators including Cr, BUN, TBIL , dBIL. Conclusion The changes of the levels of PA and RBP may participate in the early damage of liver and renal fμnction.The decrease in the levels of PA and RBP could be used for finding the early damage of organ in Children’s sepsis.
