湖南师范大学学报(医学版)
湖南師範大學學報(醫學版)
호남사범대학학보(의학판)
JOURNAL OF HUNAN NORMAL UNIVERSITY(MEDICAL SCIENCE)
2015年
2期
28-31
,共4页
席汉综合征%临床特征%腺垂体功能减退
席漢綜閤徵%臨床特徵%腺垂體功能減退
석한종합정%림상특정%선수체공능감퇴
Sheehan`s Syndrome%Clinical characteristics%Adenohypophysis hypofunction
目的:探讨119例席汉综合征患者的临床特征。方法:收集2002年1月~2014年11月在中南大学湘雅二医院内分泌科确诊为席汉综合征的119例住院患者的临床资料。结果:119例席汉综合征患者中,确诊平均年限为(18.1±11.0)年。确诊席汉综合征患者再孕12例(10%),其中长期接受激素替代6例(5%),再孕后病情缓解1例(0.8%)。并发垂体危象64例(54%),以垂体危象为首发症状者48例(75%),无垂体危象55例(46%)。促性腺激素减退症为101例(97%),促甲状腺激素减退症占103例(89%),促肾上腺皮质激素减退症占51例(100%)。尿崩症3例(3%)。49例行垂体 MRI,其中,空泡蝶鞍27例(55%),垂体萎缩19例(39%)。40例行骨密度检查,骨质疏松10例(25%),低骨量23例(58%)。结论:席汉综合征的病情轻重不一,临床表现存在多样性,早期正确诊断至关重要。一方面诊断后及时靶腺激素替代治疗可避免垂体危象、骨质疏松症等的发生,另一方面病情轻者有可能再孕,再孕后病情可改善或缓解。
目的:探討119例席漢綜閤徵患者的臨床特徵。方法:收集2002年1月~2014年11月在中南大學湘雅二醫院內分泌科確診為席漢綜閤徵的119例住院患者的臨床資料。結果:119例席漢綜閤徵患者中,確診平均年限為(18.1±11.0)年。確診席漢綜閤徵患者再孕12例(10%),其中長期接受激素替代6例(5%),再孕後病情緩解1例(0.8%)。併髮垂體危象64例(54%),以垂體危象為首髮癥狀者48例(75%),無垂體危象55例(46%)。促性腺激素減退癥為101例(97%),促甲狀腺激素減退癥佔103例(89%),促腎上腺皮質激素減退癥佔51例(100%)。尿崩癥3例(3%)。49例行垂體 MRI,其中,空泡蝶鞍27例(55%),垂體萎縮19例(39%)。40例行骨密度檢查,骨質疏鬆10例(25%),低骨量23例(58%)。結論:席漢綜閤徵的病情輕重不一,臨床錶現存在多樣性,早期正確診斷至關重要。一方麵診斷後及時靶腺激素替代治療可避免垂體危象、骨質疏鬆癥等的髮生,另一方麵病情輕者有可能再孕,再孕後病情可改善或緩解。
목적:탐토119례석한종합정환자적림상특정。방법:수집2002년1월~2014년11월재중남대학상아이의원내분비과학진위석한종합정적119례주원환자적림상자료。결과:119례석한종합정환자중,학진평균년한위(18.1±11.0)년。학진석한종합정환자재잉12례(10%),기중장기접수격소체대6례(5%),재잉후병정완해1례(0.8%)。병발수체위상64례(54%),이수체위상위수발증상자48례(75%),무수체위상55례(46%)。촉성선격소감퇴증위101례(97%),촉갑상선격소감퇴증점103례(89%),촉신상선피질격소감퇴증점51례(100%)。뇨붕증3례(3%)。49례행수체 MRI,기중,공포접안27례(55%),수체위축19례(39%)。40례행골밀도검사,골질소송10례(25%),저골량23례(58%)。결론:석한종합정적병정경중불일,림상표현존재다양성,조기정학진단지관중요。일방면진단후급시파선격소체대치료가피면수체위상、골질소송증등적발생,령일방면병정경자유가능재잉,재잉후병정가개선혹완해。
Objective To determine the clinical characteristics of 119 patients with Sheehan`s Syndrome (SS). Methods We collected the clinical data of 119 inpatients diagnosed of SS in Department of Endocrinology, the Second Xiangya Hospital , Central South University from January 2002 to November 2014. Results The mean period of diagnostic delay was(15.1± 11)years in these 119 patients with SS. 12 (10%) patients were pregnant again after being diagnosed with SS, 6(5%)of which have long-term hormone replacement therapy, 1(0.8%)of which were pregnant again Get better. 64 (54%) developed pitui-tary crisis and 55 (46%) did not, 48(75%)were pituitary crisis as first symptoms. 34(28.5%)had panhypopituitarism, while 85 (71.5%)had partial hypopituitarism. 101(97%)of the patients had gonadotropin deficiency, while 103(89%)of the patients had TSH deficiency, and 51(100%)of the patients had ACTH deficiency. diabetes insipidus were 3 case(3%). In 49 subjects having magnetic resonance imaging of pituitary, 27 (55%) showed empty sella and 19 (39%) showed pituitary involution. Moreover, 40 subjects had bone mineral density examination, 10 (25%) of which showed osteoporosis and 23 (58%) of which showed osteope-nia. Conclusion Sheehan’s syndrome of severe situation is different, clinical manifestations are diverse, early correct diagnosis is crucial. on the one hand, Prompt diagnosis and timely target gland hormone treatment can avoid pituitary crisis, osteoporosis, etc, on the other hand, Sheehan’s syndrome of slight cases may be pregnant again, pregnant again after the SS can be improved or alleviated.