河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
11期
1792-1795
,共4页
赵翠%曹俊杰%李伟%王璐%王国玉%王淼%尹成淑
趙翠%曹俊傑%李偉%王璐%王國玉%王淼%尹成淑
조취%조준걸%리위%왕로%왕국옥%왕묘%윤성숙
米氮平%舍曲林%阿尔茨海默病%抑郁
米氮平%捨麯林%阿爾茨海默病%抑鬱
미담평%사곡림%아이자해묵병%억욱
Mirtazapine%Amitriptyline%Alzheimer disease%Depression
目的:对比米氮平治疗阿尔茨海默病伴发的抑郁与舍曲林治疗的效果。方法:收集267例阿尔茨海默病伴发的抑郁患者随机分为3组,每组89例,分别为米氮平组、舍曲林组和安慰剂组,治疗周期为8周,采用康奈尔痴呆抑郁量表(CSDD量表)和Hamiltion抑郁量表(HAMD)评定临床效果。结果:舍曲林组、米氮平组与安慰剂组相比,治疗后2周的CSDD评分和HAMD评分差异均无统计学意义;治疗后4周和8周CSDD评分和HAMD评分较治疗前均有显著下降( P<0.05),两组间比较米氮平组CSDD评分和HAMD评分均较舍曲林组有显著差异( P均<0.05)。结论:米氮平治疗老年血管性痴呆伴抑郁有效,与舍曲林对比疗效相当,但副作用更少。
目的:對比米氮平治療阿爾茨海默病伴髮的抑鬱與捨麯林治療的效果。方法:收集267例阿爾茨海默病伴髮的抑鬱患者隨機分為3組,每組89例,分彆為米氮平組、捨麯林組和安慰劑組,治療週期為8週,採用康奈爾癡呆抑鬱量錶(CSDD量錶)和Hamiltion抑鬱量錶(HAMD)評定臨床效果。結果:捨麯林組、米氮平組與安慰劑組相比,治療後2週的CSDD評分和HAMD評分差異均無統計學意義;治療後4週和8週CSDD評分和HAMD評分較治療前均有顯著下降( P<0.05),兩組間比較米氮平組CSDD評分和HAMD評分均較捨麯林組有顯著差異( P均<0.05)。結論:米氮平治療老年血管性癡呆伴抑鬱有效,與捨麯林對比療效相噹,但副作用更少。
목적:대비미담평치료아이자해묵병반발적억욱여사곡림치료적효과。방법:수집267례아이자해묵병반발적억욱환자수궤분위3조,매조89례,분별위미담평조、사곡림조화안위제조,치료주기위8주,채용강내이치태억욱량표(CSDD량표)화Hamiltion억욱량표(HAMD)평정림상효과。결과:사곡림조、미담평조여안위제조상비,치료후2주적CSDD평분화HAMD평분차이균무통계학의의;치료후4주화8주CSDD평분화HAMD평분교치료전균유현저하강( P<0.05),량조간비교미담평조CSDD평분화HAMD평분균교사곡림조유현저차이( P균<0.05)。결론:미담평치료노년혈관성치태반억욱유효,여사곡림대비료효상당,단부작용경소。
Objective:To evaluate the efficacy of mirtazapine and sertraline on depression Induced by alzheimer disease .Method:267 cases of elderly patients of dementia with depression in our hospital outpa-tient,they were randomly divided into three groups , the mirtazapine group (89 cases),sertraline group (89 cases)and control group (89 cases) for a period of eight weeks, using HAMD, CSDD rating scale to evalu-ate clinical effects .Result:There were significant difference between mirtazapine group ,sertraline group and control group HAMD and CSDD scores .Mirtazapine incidence of side effects , was higher than that of sertra-line group.Conclusion:It is suitable for the elderly patients that mirtazapine and sertraline have the equiva-lent therapeutic effects in the treatment of geriatric depression .