湖南师范大学学报（医学版）
湖南師範大學學報（醫學版）
호남사범대학학보（의학판）
JOURNAL OF HUNAN NORMAL UNIVERSITY(MEDICAL SCIENCE)
2015年
2期
60-62
,共3页
乙型肝炎病毒%前 S1 抗原%HBV-DNA%HbeAg
乙型肝炎病毒%前 S1 抗原%HBV-DNA%HbeAg
을형간염병독%전 S1 항원%HBV-DNA%HbeAg
Hepatitis B virus%S1 antigen%HBV-DNA%HbeAg
目的：研究与分析乙型肝炎病毒前 S1抗原检测意义，并探讨 S1抗原与病毒复制间关系。方法：选取78例乙型肝炎患者进行研究，并采用荧光定量法和酶联免疫吸附法检测患者血清乙型肝炎病毒 e 抗原(HbeAg)和前 S1抗原及乙型肝炎病毒脱氧核糖核酸(HBV-DNA)。结果：经检测发现，78例患者中，前 S1抗原阳性率为78.21%(61/78)；HBV-DNA 阳性率为87.18%(68/78)；HbeAg 阳性率为56.41%(44/78)，在 HbeAg 阳性患者中前 S1抗原阳性率为79.55%(35/44)、HBV-DNA 阳性率为86.36%(38/44)，前 S1抗原阳性率与 HBV-DNA 阳性率比较无显著差异。68例 HBV-DNA 阳性患者中，前 S1抗原阳性率为86.76%(59/68)、HbeAg 阳性率为57.35%(39/68)，前 S1抗原阳性率明显高于 HbeAg 阳性率。结论：HBV-DNA 与乙型肝炎病毒前 S1抗原存在紧密联系，同时乙型肝炎病毒前 S1抗原是乙型肝炎患者体内复制重要指标。
目的：研究與分析乙型肝炎病毒前 S1抗原檢測意義，併探討 S1抗原與病毒複製間關繫。方法：選取78例乙型肝炎患者進行研究，併採用熒光定量法和酶聯免疫吸附法檢測患者血清乙型肝炎病毒 e 抗原(HbeAg)和前 S1抗原及乙型肝炎病毒脫氧覈糖覈痠(HBV-DNA)。結果：經檢測髮現，78例患者中，前 S1抗原暘性率為78.21%(61/78)；HBV-DNA 暘性率為87.18%(68/78)；HbeAg 暘性率為56.41%(44/78)，在 HbeAg 暘性患者中前 S1抗原暘性率為79.55%(35/44)、HBV-DNA 暘性率為86.36%(38/44)，前 S1抗原暘性率與 HBV-DNA 暘性率比較無顯著差異。68例 HBV-DNA 暘性患者中，前 S1抗原暘性率為86.76%(59/68)、HbeAg 暘性率為57.35%(39/68)，前 S1抗原暘性率明顯高于 HbeAg 暘性率。結論：HBV-DNA 與乙型肝炎病毒前 S1抗原存在緊密聯繫，同時乙型肝炎病毒前 S1抗原是乙型肝炎患者體內複製重要指標。
목적：연구여분석을형간염병독전 S1항원검측의의，병탐토 S1항원여병독복제간관계。방법：선취78례을형간염환자진행연구，병채용형광정량법화매련면역흡부법검측환자혈청을형간염병독 e 항원(HbeAg)화전 S1항원급을형간염병독탈양핵당핵산(HBV-DNA)。결과：경검측발현，78례환자중，전 S1항원양성솔위78.21%(61/78)；HBV-DNA 양성솔위87.18%(68/78)；HbeAg 양성솔위56.41%(44/78)，재 HbeAg 양성환자중전 S1항원양성솔위79.55%(35/44)、HBV-DNA 양성솔위86.36%(38/44)，전 S1항원양성솔여 HBV-DNA 양성솔비교무현저차이。68례 HBV-DNA 양성환자중，전 S1항원양성솔위86.76%(59/68)、HbeAg 양성솔위57.35%(39/68)，전 S1항원양성솔명현고우 HbeAg 양성솔。결론：HBV-DNA 여을형간염병독전 S1항원존재긴밀련계，동시을형간염병독전 S1항원시을형간염환자체내복제중요지표。
Objective Research and analysis of hepatitis B virus S1 antigen detection significance,and to explore the rela-tionship between S1 antigen and viral replication. Methods The study of 78 patients with hepatitis B, and the fluorescent quan-titative assay and enzyme-linked immunosorbent assay in serum in patients with chronic hepatitis B virus e antigen (HbeAg) and pre S1 antigen and hepatitis B virus deoxyribonucleic acid (HBV-DNA). Results After testing found that,among the 78 pa-tients, the positive rate of S1 antigen was 78.21% (61/78); the positive rate of HBV-DNA was 87.18% (68/78); the positive rate of HbeAg was 56.41% (44/78), the positive rate of S1 antigen was 79.55% (35/44), the positive rate of HBV-DNA was 86.36% (38/44) to compare the positive rate, positive rate before S1 antigen 79.55% and HBV-DNA 86.36%. In 68 cases of HBV-DNA positive,the positive rate of S1 antigen was 86.76% (59/68), the positive rate of HBV-DNA was 57.35% (39/68), positive rate of S1 antigen positive rate of 86.76% with HBV-DNA 57.35% (P<0.05). Conclusion HBV-DNA and hepatitis B virus S1 antigen are linked, and hepatitis B virus S1 antigen is an important index in patients with hepatitis B replication in vivo.
