CAJ | 학술논문

目的：：分析国内不同年龄阶段患者临床分离菌对头孢曲松的耐药情况。方法：对2009至2014年公开发表的关于头孢曲松细菌耐药性检测的文章进行检索，按一定的纳入和排除标准进行统计和分析。结果：儿童患者阳性菌以肺炎链球菌、流感嗜血杆菌、溶血性链球菌为主，对CRO的耐药率均低于20%。成年患者阳性菌主要为溶血性链球菌、流感嗜血杆菌和副流感嗜血杆菌，耐药率均低于30%，而耐甲氧西林葡萄球菌的耐药率为100%，老年患者检出了较大比例的葡萄球菌，耐药率超过60%，对于阴性菌感染，各年龄阶段均检出了较高比例的大肠挨希菌和肺炎克雷伯菌，其耐药率均超过50%。结论：不同年龄阶段患者阴性菌和老年患者阳性菌对CRO的耐药已非常严重，应进一步做好细菌耐药监测和抗菌药物的合理使用。
목적：：분석국내불동년령계단환자림상분리균대두포곡송적내약정황。방법：대2009지2014년공개발표적관우두포곡송세균내약성검측적문장진행검색，안일정적납입화배제표준진행통계화분석。결과：인동환자양성균이폐염련구균、류감기혈간균、용혈성련구균위주，대CRO적내약솔균저우20%。성년환자양성균주요위용혈성련구균、류감기혈간균화부류감기혈간균，내약솔균저우30%，이내갑양서림포도구균적내약솔위100%，노년환자검출료교대비례적포도구균，내약솔초과60%，대우음성균감염，각년령계단균검출료교고비례적대장애희균화폐염극뢰백균，기내약솔균초과50%。결론：불동년령계단환자음성균화노년환자양성균대CRO적내약이비상엄중，응진일보주호세균내약감측화항균약물적합리사용。
Objective:To investigate the drug resistant trend of ceftriaxone ( CRO) from patients of different ages. Methods:The references related to ceftriaxone resistance were gathered by the CNKI database during 2009-2014,and discussed by statistics and analysis according to some inclusion criteria and exclusion criteria. Results:The main strains detected from children were Streptococcus pneumonia,Haemophilus influenza and Hemolytic streptococcus which the drug resistance rates were all below 20%. And the main strains detected from adults were Hemolytic streptococcus,Haemophilus influenza and Haemophilus parainfluenzae which the drug re-sistance rate were all above 60%, but the drug resistance rate of Methicillin resistant Staphylococcus aureus was 100%. Detection of most strains from gerontism was Staphylococcus and its resistance rate was above 60%. For the injections of gram-negative bacteria, the detection rate of Escherichia coli and Klebsiella pneumonia were in a high proportion of different age stage,and resistance rate of them were all above 50%. Conclusion:The status of drug-resistance of gram-negative bacteria detected from all age stage and gram-positive detected from gerontism were very serious,and thus needs more management in drug resistance surveillance and rational use of antibiotics.