微生物学免疫学进展
微生物學免疫學進展
미생물학면역학진전
PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY
2015年
4期
69-74
,共6页
童彦军(综述)%谢溱%蒋琳(审校)
童彥軍(綜述)%謝溱%蔣琳(審校)
동언군(종술)%사진%장림(심교)
VLPs%VLPs组装%VLP疫苗设计%VLP疫苗
VLPs%VLPs組裝%VLP疫苗設計%VLP疫苗
VLPs%VLPs조장%VLP역묘설계%VLP역묘
VLPs%VLPs assembly mechanism%VLP vaccine design%VLP vaccines
随着传统疫苗的升级换代，疫苗的研制越来越多的借助于基因工程手段，其中病毒样颗粒（VLPs）成为了当今病毒性疫苗研究的热点，尤其对于不易在体外大规模培养的病毒，VLPs是研发其疫苗的突破口。关于VLPs及其疫苗的研究，从球状病毒的组装理论、病毒的VLPs组装、VLP疫苗设计和VLP疫苗等几个方面予以综述。
隨著傳統疫苗的升級換代，疫苗的研製越來越多的藉助于基因工程手段，其中病毒樣顆粒（VLPs）成為瞭噹今病毒性疫苗研究的熱點，尤其對于不易在體外大規模培養的病毒，VLPs是研髮其疫苗的突破口。關于VLPs及其疫苗的研究，從毬狀病毒的組裝理論、病毒的VLPs組裝、VLP疫苗設計和VLP疫苗等幾箇方麵予以綜述。
수착전통역묘적승급환대，역묘적연제월래월다적차조우기인공정수단，기중병독양과립（VLPs）성위료당금병독성역묘연구적열점，우기대우불역재체외대규모배양적병독，VLPs시연발기역묘적돌파구。관우VLPs급기역묘적연구，종구상병독적조장이론、병독적VLPs조장、VLP역묘설계화VLP역묘등궤개방면여이종술。
With the upgrading of traditional vaccines, the vaccine development increasingly depends on the genetic engi-neering techniques, where the virus-like particles (VLPs) has become a hot spot for today’s vaccine research, especially for the viruses which could not be achieved at present by way of large-scale cultivation in vitro.VLPs has become a break-through in the development of such vaccines.This article will look at the following aspects for a summary, including the as-sembly theory of spherical virus, the VLPs assembly mechanism of several viruses, the VLP vaccine design and the VLP vaccines.
