微生物学免疫学进展
微生物學免疫學進展
미생물학면역학진전
PROGRESS IN MICROBIOLOGY AND IMMUNOLOGY
2015年
4期
1-15
,共15页
杆状病毒%昆虫细胞%杆状病毒表达载体系统%疫苗
桿狀病毒%昆蟲細胞%桿狀病毒錶達載體繫統%疫苗
간상병독%곤충세포%간상병독표체재체계통%역묘
Baculovirus%Insect cell%Baculovirus expression vector system%Vaccine
1983年12月，一篇关于用昆虫杆状病毒感染昆虫细胞表达重组人β干扰素文章的发表，标示了杆状病毒表达载体系统（ Baculovirus expression vector system，BEVS）的诞生。迄今为止，已采用BEVS表达生产了数千种重组蛋白，其中7种已被成功用于商品化人用或兽用疫苗的抗原。仅对30年来基于BEVS的疫苗研制作一论述。
1983年12月，一篇關于用昆蟲桿狀病毒感染昆蟲細胞錶達重組人β榦擾素文章的髮錶，標示瞭桿狀病毒錶達載體繫統（ Baculovirus expression vector system，BEVS）的誕生。迄今為止，已採用BEVS錶達生產瞭數韆種重組蛋白，其中7種已被成功用于商品化人用或獸用疫苗的抗原。僅對30年來基于BEVS的疫苗研製作一論述。
1983년12월，일편관우용곤충간상병독감염곤충세포표체중조인β간우소문장적발표，표시료간상병독표체재체계통（ Baculovirus expression vector system，BEVS）적탄생。흘금위지，이채용BEVS표체생산료수천충중조단백，기중7충이피성공용우상품화인용혹수용역묘적항원。부대30년래기우BEVS적역묘연제작일논술。
In December, 1983, a seminal paper was published to introduce the expression of human interferon-βin insect cells infected with a genetically engineered baculovirus ( BV) ,denoting the birth of baculovirus expression vector system ( BEVS) .Up to date, thousands of recombinant proteins have been produced using the BEVS, including recombinant pro-teins used as antigens in 7 commercialized human and veterinary vaccines in current market.The purpose of this paper is to review the research and development of vaccines based on the BEVS over the 30-years since 1983, while noting the work for further improvements.
