CAJ | 학술논문

目的：探讨中枢神经细胞瘤的临床、影像学及病理特点，旨在提高对该肿瘤的诊断水平。方法回顾性分析12例经手术病理证实的中枢神经细胞瘤的临床症状、影像学及病理学的表现。结果11例肿瘤均位于侧脑室透明隔，邻近 Monro 孔，1例位于右侧小脑半球，肿瘤形态均不规则，界限清楚。5例肿瘤行 CT 平扫，4例见不同程度钙化征象，呈混杂密度，实性部分呈稍高密度。 MRI 平扫，多数肿瘤 T1 WI 呈等、低信号，T2 WI 呈不均匀等、稍高信号。8例肿瘤呈囊实性，囊性部分主要位于病灶边缘部。 T2 WI 3例病灶呈“海绵征”，4例病灶呈“冒泡征”改变，增强扫描囊变区间的索条样分隔中等强化，呈“丝瓜瓤”状改变。增强检查8例肿瘤实质部分呈中等‐明显不均匀强化，5例肿瘤内可见粗大的血管影。病理检查见肿瘤由形态一致的小圆细胞组织，其内血管丰富。免疫组化染色：突触素和神经元特异性烯醇化酶呈阳性。结论中枢神经细胞瘤临床表现、MRI 及病理学表现有一定的特征性，结合年龄及典型发病部位特点，有助于与其他脑室内肿瘤鉴别。
목적：탐토중추신경세포류적림상、영상학급병리특점，지재제고대해종류적진단수평。방법회고성분석12례경수술병리증실적중추신경세포류적림상증상、영상학급병이학적표현。결과11례종류균위우측뇌실투명격，린근 Monro 공，1례위우우측소뇌반구，종류형태균불규칙，계한청초。5례종류행 CT 평소，4례견불동정도개화정상，정혼잡밀도，실성부분정초고밀도。 MRI 평소，다수종류 T1 WI 정등、저신호，T2 WI 정불균균등、초고신호。8례종류정낭실성，낭성부분주요위우병조변연부。 T2 WI 3례병조정“해면정”，4례병조정“모포정”개변，증강소묘낭변구간적색조양분격중등강화，정“사과양”상개변。증강검사8례종류실질부분정중등‐명현불균균강화，5례종류내가견조대적혈관영。병리검사견종류유형태일치적소원세포조직，기내혈관봉부。면역조화염색：돌촉소화신경원특이성희순화매정양성。결론중추신경세포류림상표현、MRI 급병이학표현유일정적특정성，결합년령급전형발병부위특점，유조우여기타뇌실내종류감별。
Objective To investigate the clinical ,radiologic and pathological features of the central neurocytoma (CNC) in order to improve diagnostic level .Methods 12 patients with CNC were confirmed by surgy and pathology and the clini‐cal ,radiologicand pathological features of them were retrospectively reviewed .Results 11 lesions located in the lateral ventricle septum pellucidum ,adjacent to Monro hole ,and one lesion located in the right cerebellum hemisphere ,with ir‐rugular shape and sharp edge .5 patients underwent CT plain scans ,4 cases presented with different degrees of calcifica‐tion ,and their density was inhomogeneity ,with higher density for solid component .The majority presented as hypoin‐tense and equal signal intensity on T1 WI and inhomogeneous hyperintense signal on T2 WI .8 cases showed cyst‐ solidary , with multiple cystic degeneration in the borders of the tumors .On T2 WI ,3 cases showed “spongy” sign and 4 cases showed a “soap bubble” appearance ,of these case ,surrounding the cystic part showed “sponge gourd” patternlike areas on the postcontrast MRI .The postcontrast MR revealed solid part of 8 lesions demonstrated moderate or obvious enhance‐ment ,the thick enhanced vessels were found in 5 patients .All tumours were composed of monotonous neoplastic cells , and riched in blood vessels .The immunohistochemistry revealed syn(+ ) and NSE(+ ) .Conclusion CNC has the charac‐teristic appearances on MRI ,pathology and clinical data .When compaired with the onset age and typical part ,it will be helpful to the diagnosis and differentiates the neurocytoma from other tumors residing in lateral ventricle .