CAJ | 학술논문

在慢性牙周炎的发生发展过程中，牙周组织破坏的致病机理包括细菌的直接破坏和宿主的免疫炎症反应，其中宿主的免疫炎症反应发挥关键作用已得到公认。宿主的免疫炎症反应对牙周致病菌及其毒性产物具有防御作用，但牙周组织中持续存在的免疫炎症反应在杀菌作用的同时也产生大量的促炎因子，从而导致牙槽骨的吸收。目前，情绪应激等导致交感神经系统的激活已成为慢性牙周炎发生和发展的重要危险因素。机体交感神经纤维所释放的去甲肾上腺素对免疫细胞的功能具有调控作用。因此交感神经系统可通过直接或间接作用参与慢性牙周炎的发展过程。本文就肾上腺素能受体信号对免疫细胞的功能调控及其在慢性牙周炎中的作用作一综述。
재만성아주염적발생발전과정중，아주조직파배적치병궤리포괄세균적직접파배화숙주적면역염증반응，기중숙주적면역염증반응발휘관건작용이득도공인。숙주적면역염증반응대아주치병균급기독성산물구유방어작용，단아주조직중지속존재적면역염증반응재살균작용적동시야산생대량적촉염인자，종이도치아조골적흡수。목전，정서응격등도치교감신경계통적격활이성위만성아주염발생화발전적중요위험인소。궤체교감신경섬유소석방적거갑신상선소대면역세포적공능구유조공작용。인차교감신경계통가통과직접혹간접작용삼여만성아주염적발전과정。본문취신상선소능수체신호대면역세포적공능조공급기재만성아주염중적작용작일종술。
In the development of chronic periodontitis, the mechanisms of the destruction of periodontal tis-sues include direct damages caused by bacteria and inflammatory reactions of the host, of which the inflammation has been recognized to play a key role. The host immune reactions protect against bacterial plaques and their toxic prod-ucts. However at the same time, the persistent abnormal activation of immune reactions results in overproduction of pro-inflammatory cytokines, leading to resorption of the alveolar bone. For now, activation of sympathetic nervous system ( SNS) by emotional stress has become a major risk factor for chronic periodontitis. Many studies have discov-ered regulatory capacity of norepinephrine (NE), the primary neurotransmitter secreted by SNS, on the functions of immune cells, thus the host SNS directly or indirectly participates in the development of chronic periodontitis. This re-view focuses on the regulatory effects of adrenergic signals on the function of immune cells in chronic periodontitis.