CAJ | 학술논문

慢性放射性肠炎（ CRE）是盆腔、腹腔、腹膜后恶性肿瘤经放射治疗引起的肠道并发症之一。 CRE主要是由于电离产生的自由基对肠黏膜细胞的损伤导致的，造成的损伤主要包括：肠上皮细胞增生受抑制，肠黏膜下小动脉受损及肠壁组织慢性纤维化；CRE的临床表现为反复发作的便血、腹泻、腹痛，严重者出现肠梗阻、肠穿孔等，外科手术是CRE合并肠梗阻的最终治疗手段，本文就CRE的流行病学，发病机制及临床治疗的最新研究进展予以综述。
만성방사성장염（ CRE）시분강、복강、복막후악성종류경방사치료인기적장도병발증지일。 CRE주요시유우전리산생적자유기대장점막세포적손상도치적，조성적손상주요포괄：장상피세포증생수억제，장점막하소동맥수손급장벽조직만성섬유화；CRE적림상표현위반복발작적편혈、복사、복통，엄중자출현장경조、장천공등，외과수술시CRE합병장경조적최종치료수단，본문취CRE적류행병학，발병궤제급림상치료적최신연구진전여이종술。
Chronic radiation enteritis ( CRE) is a common serious complication in patients receiving abdominal or pelvic irradiation in the course of cancer treatment.CRE is mainly due to free radicals generated by ionization, which causes dam-age to the intestinal mucosal cells.In this process, intestinal epithelial cell proliferation is inhibited, sub-mucosal arteri-oles occlusion and intestinal fibrosis is induced.The main clinical manifestations of CRE are blood in stool, diarrhea and abdominal pain.In severe cases, intestinal obstruction and perforation may happen.Surgical treatment is the ultimate treat-ment for CRE induced-intestinal obstruction.In this paper, we review the epidemiology, pathology and treatment of CRE.