CAJ | 학술논문

目的：回顾性调查胎膜早破（ premature rupture of membrane，PROM）在大样本孕妇人群中发病情况，为深入了解该病特点及协助孕期管控提供依据。方法选取2544例孕妇进行回顾性分析，采集孕妇人口学特征、孕产史、孕期维生素服用情况及孕期患病情况，以不同条件分组，统计各组PROM发病率，分析PROM发生的潜在危险因素。结果（1）2544例孕妇，发生PROM共392例，发生率为15．4％；（2）受教育程度低、孕期被动吸烟、孕期发生泌尿生殖道感染、孕期合并或并发糖尿病以及孕期服用复合维生素时间较长的孕妇PROM发生率显著升高（ P＜0．05）；（3）随年龄和流产次数增加，PROM发生率呈升高趋势（ P＜0．05）。结论高龄、学历低、多次流产史、被动吸烟、泌尿生殖道感染、孕期糖尿病以及孕期服用复合维生素时间长可能是孕妇发生PROM的危险因素；孕期服用复合维生素与PROM发生的关系值得进一步研究。
목적：회고성조사태막조파（ premature rupture of membrane，PROM）재대양본잉부인군중발병정황，위심입료해해병특점급협조잉기관공제공의거。방법선취2544례잉부진행회고성분석，채집잉부인구학특정、잉산사、잉기유생소복용정황급잉기환병정황，이불동조건분조，통계각조PROM발병솔，분석PROM발생적잠재위험인소。결과（1）2544례잉부，발생PROM공392례，발생솔위15．4％；（2）수교육정도저、잉기피동흡연、잉기발생비뇨생식도감염、잉기합병혹병발당뇨병이급잉기복용복합유생소시간교장적잉부PROM발생솔현저승고（ P＜0．05）；（3）수년령화유산차수증가，PROM발생솔정승고추세（ P＜0．05）。결론고령、학력저、다차유산사、피동흡연、비뇨생식도감염、잉기당뇨병이급잉기복용복합유생소시간장가능시잉부발생PROM적위험인소；잉기복용복합유생소여PROM발생적관계치득진일보연구。
Objective To survey the incidence of premature rupture of membrane ( PROM) in a large sample of pregnant women to provide a basis for further understanding the disease and its clinical treatment.Methods We enrolled 2544 preg-nant women in the study and conducted a retrospective analysis.Demographic characteristics were investigated.Potential risk factors were analyzed.Results ( 1 ) In 2544 pregnant women, 392 patients had PROM with an incidence rate of 15.4%.(2) Mothers with lower education and urinary and reproductive system infection, exposed to passive smoking, complicated with diabetes mellitus and taking vitamin compound preparations for relatively long time during pregnancy had significantly higher incidence of PROM (P<0.05).(3) Incidence of PROM increased with maternal age and times of a-bortion (P<0.05).Conclusions Some demographic characteristics, repeated abortion history and some adverse events during pregnancy are associated with risk of PROM.The relationship between intake of vitamin compound preparations and PROM is worth to be studied further.