CAJ | 학술논문

目的：探讨血清瘦素（ leptin， Lp）和可溶性瘦素受体（ soluble leptin receptor， sLR）与系统性红斑狼疮（ systemic lupus erythematosus， SLE）发病及病情的关系。方法采用ELISA方法检测大连医科大学附属第一医院风湿科收治的87例SLE患者和85例健康对照者血清Lp和sLR浓度，并将SLE患者分为活动期组和稳定期组、合并狼疮肾炎组和无狼疮肾炎组、合并关节症状组和无关节症状组分别进行统计分析。分析SLE患者血清Lp和sLR水平与病程、体重指数（ BMI ）、血沉、血红蛋白、血小板、抗核抗体、抗双链DNA抗体、免疫球蛋白（ IgG、IgA、IgM）、补体（ C3、C4）、SLEDAI评分等临床指标的相关性。结果 SLE组血清Lp水平（7．06±3．19） ng／mL高于健康对照组（5．36±2．66） ng／mL（P＜0．05）；血清sLR水平与健康对照组差异无显著性意义（P＞0．05）。血清Lp和sLR水平在SLE活动期组和稳定期组，狼疮肾炎组和无狼疮肾炎组，有关节症状和无关节症状组均无明显差异（P＞0．05）。SLE 患者血清Lp水平与BMI呈正相关（r＝0．375，P＝0．022），与sLR 呈负相关（r＝－0．219，P＝0．041）。 SLE患者血清sLR水平与血沉、IgG、IgA、IgM均呈正相关（r＝0．387，P＝0．001；r＝0．336，P＝0．009； r＝0．331，P＝0．010；r＝0．366，P＝0．004），与其它临床指标无相关性。结论 SLE患者血清Lp水平显著升高，Lp的水平变化可能与SLE的发病密切相关，但血清Lp和sLR浓度尚不能作为SLE病情评价及监测的指标。
목적：탐토혈청수소（ leptin， Lp）화가용성수소수체（ soluble leptin receptor， sLR）여계통성홍반랑창（ systemic lupus erythematosus， SLE）발병급병정적관계。방법채용ELISA방법검측대련의과대학부속제일의원풍습과수치적87례SLE환자화85례건강대조자혈청Lp화sLR농도，병장SLE환자분위활동기조화은정기조、합병랑창신염조화무랑창신염조、합병관절증상조화무관절증상조분별진행통계분석。분석SLE환자혈청Lp화sLR수평여병정、체중지수（ BMI ）、혈침、혈홍단백、혈소판、항핵항체、항쌍련DNA항체、면역구단백（ IgG、IgA、IgM）、보체（ C3、C4）、SLEDAI평분등림상지표적상관성。결과 SLE조혈청Lp수평（7．06±3．19） ng／mL고우건강대조조（5．36±2．66） ng／mL（P＜0．05）；혈청sLR수평여건강대조조차이무현저성의의（P＞0．05）。혈청Lp화sLR수평재SLE활동기조화은정기조，랑창신염조화무랑창신염조，유관절증상화무관절증상조균무명현차이（P＞0．05）。SLE 환자혈청Lp수평여BMI정정상관（r＝0．375，P＝0．022），여sLR 정부상관（r＝－0．219，P＝0．041）。 SLE환자혈청sLR수평여혈침、IgG、IgA、IgM균정정상관（r＝0．387，P＝0．001；r＝0．336，P＝0．009； r＝0．331，P＝0．010；r＝0．366，P＝0．004），여기타림상지표무상관성。결론 SLE환자혈청Lp수평현저승고，Lp적수평변화가능여SLE적발병밀절상관，단혈청Lp화sLR농도상불능작위SLE병정평개급감측적지표。
Objective To investigate the serum levels of leptin and soluble leptin receptor in patients with systemic lupus erythematosus ( SLE) and to analyze their correlation with SLE disease activity and clinical parameters.Methods Serum leptin and soluble leptin receptor levels of 87 patients with SLE and 85 matched healthy controls were measured by ELISA assays.The liner correlation analysis was used to evaluate the relationship between levels of leptin and soluble leptin recep-tor with their clinical parameters.Results Compared to normal controls, serum level of leptin was significant higher in SLE patients [(7.06 ±3.19) ng/mL vs.(5.36 ±2.66) ng/mL, P<0.05].No significant difference was found in soluble leptin receptor levels between SLE patients and controls.Furthermore there were no differences in the levels of leptin and soluble leptin receptor between active and inactive SLE patients, patients with and without lupus nephritis ( LN) and pa-tient with and without arthritis, respectively.A positive association was observed between leptin levels in SLE patients and body mass index (BMI) (r=0.375, P=0.022);a negative correlation was observed between leptin and soluble leptin re-ceptor levels in SLE patients (r =-0.219, P =0.041).The serum soluble leptin receptor levels were positively correlatedwith ESR, IgG, IgA and IgM (r =0.387, P =0.001; r =0.336, P =0.009; r =0.331, P =0.010; r =0.366, P =0.004, respectively).Conclusion Abnormal levels of leptin might be involved in the pathogenesis of SLE.However, levelsof serum leptin and soluble leptin receptor could not be used as a clinical index to evaluate the severity of SLE.