CAJ | 학술논문

原发性胆汁性肝硬化（ PBC）目前发病机制尚不明确。临床上很多患者的诊断仍主要靠肝组织活检，迫切需要寻找更简便可靠的诊断方法。应用核磁共振（ NMR）技术检测 PBC 患者血清代谢物组，在近年来得到飞速发展。但该技术尚未成熟，目前未广泛应用于临床。该文就代谢组学的概况、NMR检测血清代谢物组的相关研究进展及其在PBC诊断中的应用予以综述，为该技术应用于临床做准备。
원발성담즙성간경화（ PBC）목전발병궤제상불명학。림상상흔다환자적진단잉주요고간조직활검，박절수요심조경간편가고적진단방법。응용핵자공진（ NMR）기술검측 PBC 환자혈청대사물조，재근년래득도비속발전。단해기술상미성숙，목전미엄범응용우림상。해문취대사조학적개황、NMR검측혈청대사물조적상관연구진전급기재PBC진단중적응용여이종술，위해기술응용우림상주준비。
Primary biliary cirrhosis( PBC) pathogenesis is not clear at present,and the diagnosis of many patients still mainly relies on liver biopsy ,so there is an urgent need to find a more convenient and reliable diagnostic method.Using nuclear magnetic resonance ( NMR) to detect serum metabolites group in patients with PBC is a rapid development in recent years,though the technology is not yet mature,and not widely used in clinical practice currently.Here is to make a review of metabolomics research progress related to serum metabolomic NMR and its application in the diagnosis of PBC to prepare for the clinical application of the technology.