CAJ | 학술논문

CUEDC2是由国内学者张学敏于2007年首次报道的一种蛋白分子,由于其能够促进孕激素受体发生降解,引起了研究者的极大兴趣。随着研究的不断深入,CUEDC2在一些细胞重要的生理调控活动中发挥的关键性作用被相继阐明。目前发现,CUEDC2参与了细胞周期调控和细胞信号转导,并与某些肿瘤的发生发展密切相关。根据现有相关文献,对CUEDC2的结构以及有关功能的研究进展进行综述。
CUEDC2시유국내학자장학민우2007년수차보도적일충단백분자,유우기능구촉진잉격소수체발생강해,인기료연구자적겁대흥취。수착연구적불단심입,CUEDC2재일사세포중요적생리조공활동중발휘적관건성작용피상계천명。목전발현,CUEDC2삼여료세포주기조공화세포신호전도,병여모사종류적발생발전밀절상관。근거현유상관문헌,대CUEDC2적결구이급유관공능적연구진전진행종술。
CUEDC2 protein promoting progesterone receptor degradation first reported by the team of academician Zhang Xue-min in EMBO J 2007 is a kind of important proteins whose functions are still not clear. With the deeper research ,CUEDC2 plays a key role in a number of important physiological regulation of cellular events causing great concern of researchers. So far ,The important regu-latory mechanism in cell cycle ,signal transduction pathways ,developments of tumors and so on involving CUEDC2 has been publicly reported. According to available literature,the progresses in structure and functions of CUEDC2 are summarized.