CAJ | 학술논문

目的：研究姜黄素PLGA－TPGS纳米粒（ Curcumin－loaded PLGA－TPGS Nanoparticles，CPTN）在小鼠体内的分布及对肝脏的靶向性。方法经小鼠尾静脉注射CPTN和姜黄素溶液（ Curcumin solutions，CS），采用反相高效液相色谱法测定不同时间时姜黄素在小鼠血浆、肝、心、脾、肺、肾中的浓度。用靶向指数（ targeting index，TI）、选择性指数（selective index，SI）、相对靶向效率（relative targeting efficiency，Re）和靶向效率（targeting efficiency，Te）4个指标全面评价CPTN对肝脏的靶向性。结果 CPTN组1、2、4 h时肝内药物浓度远高于血浆、脾、肺（P＜0．05）和心、肾（P＜0．01），药物持续作用时间明显长于CS组；TI和SI值均＞1（SI在0．08 h和0．5 h除外），CPTN在肝中的AUC是CS在肝中AUC的31．6倍，且CPTN组的Te值均＞3。结论 CPTN对肝脏有良好的靶向作用。
목적：연구강황소PLGA－TPGS납미립（ Curcumin－loaded PLGA－TPGS Nanoparticles，CPTN）재소서체내적분포급대간장적파향성。방법경소서미정맥주사CPTN화강황소용액（ Curcumin solutions，CS），채용반상고효액상색보법측정불동시간시강황소재소서혈장、간、심、비、폐、신중적농도。용파향지수（ targeting index，TI）、선택성지수（selective index，SI）、상대파향효솔（relative targeting efficiency，Re）화파향효솔（targeting efficiency，Te）4개지표전면평개CPTN대간장적파향성。결과 CPTN조1、2、4 h시간내약물농도원고우혈장、비、폐（P＜0．05）화심、신（P＜0．01），약물지속작용시간명현장우CS조；TI화SI치균＞1（SI재0．08 h화0．5 h제외），CPTN재간중적AUC시CS재간중AUC적31．6배，차CPTN조적Te치균＞3。결론 CPTN대간장유량호적파향작용。
Objective To study the distribution of Curcumin-loaded polylactic-co-glycolic acid-D-α-tocopherol polyethylene glycol 1000 succinate nanoparticles ( CPTN) and the liver targeting in mice.Methods The mice were given CPTN and Curcumin solutions ( CS) by tail vein injection.The concentration changes of Curcumin in plasma,liver,heart, spleen,lung,kidney of mice were determined at different time by reverse phase-high performance liquid chromatography ( RP-HPLC) ,and evaluated using TI,SI,Re and Te four index to evaluate the hepatic targeting of CPTN.Results Intrahe-patic drug concentration of CPTN at 1, 2, 4 h was higher than that of plasma, spleen, lung (P<0.05) and heart, kidney ( P<0.01) respectively, and longer drug duration than CS.TI and SI were both greater than 1 at the different intervals ex-cept for SI at 0.08 h and 0.5 h.Re of CPTN in liver was 31.6 folds than that of CS in liver, and Te of CPTN group>3. Conclusion CPTN has good targeting property in vivo for the liver.