CAJ | 학술논문

目的：研究大肠癌中医证型的分布规律，以临床常见证型为研究对象，进一步探讨大肠癌中医证候的演变及疗效规律。方法对383例大肠癌患者进行资料整理及统计学分析。结果大肠癌中医证型分布规律为：按虚实辨证，实证＞虚证＞虚实夹杂证；按脏腑辨证，脾＞肾＞肝＞心＞肺；按临床证型辨证，湿热下迫型＞脾肾亏虚型＞大肠瘀毒型。大肠癌演变规律为：由实证或虚实夹杂证演变为虚证，表现为湿热下迫→脾肾亏虚，大肠瘀毒→脾肾亏虚。大肠癌疗效规律为：湿热下迫型与大肠瘀毒型患者均能显著提高体质量。同一证型治疗后与治疗前对比KPS评分差异有统计学意义。湿热下迫型与大肠瘀毒型CEA差异有统计学意义，大肠瘀毒型CEA最高，阳性率各型差异无统计学意义。湿热下迫型患者能耐受更多疗程的化疗。结论大肠癌中医证型分布具有一定规律性，其中以实证、归于脾肾、湿热下迫型最为常见；其证候均有从实转虚的变化；不同中医证型均可以提高大肠癌患者体质量、改善生活质量、降低CEA、耐受不同程度的化疗数量，实证疗效更好。
목적：연구대장암중의증형적분포규률，이림상상견증형위연구대상，진일보탐토대장암중의증후적연변급료효규률。방법대383례대장암환자진행자료정리급통계학분석。결과대장암중의증형분포규률위：안허실변증，실증＞허증＞허실협잡증；안장부변증，비＞신＞간＞심＞폐；안림상증형변증，습열하박형＞비신우허형＞대장어독형。대장암연변규률위：유실증혹허실협잡증연변위허증，표현위습열하박→비신우허，대장어독→비신우허。대장암료효규률위：습열하박형여대장어독형환자균능현저제고체질량。동일증형치료후여치료전대비KPS평분차이유통계학의의。습열하박형여대장어독형CEA차이유통계학의의，대장어독형CEA최고，양성솔각형차이무통계학의의。습열하박형환자능내수경다료정적화료。결론대장암중의증형분포구유일정규률성，기중이실증、귀우비신、습열하박형최위상견；기증후균유종실전허적변화；불동중의증형균가이제고대장암환자체질량、개선생활질량、강저CEA、내수불동정도적화료수량，실증료효경호。
Objective ToobservetheTCMSyndromedistributionregularityofcolorectalcancerandfurtherdiscuss theevolvementandefficacyregularitywithclinicaltypeforexample.Methods Aretrospectiveanalysisof383patients withcolorectalcancerwasmade.Results TCMsyndromedistributionregularitywasempirical>deficiency>both deficiency and empirical by syndrome differentiation of excess and deficiency;spleen> kidney> liver> heart> lung by syndrome differentiation of zang-fu viscera;damp-heat type> spleen and kidney deficiency type> colon blood sta-sis type by clinical type. TCM Syndrome evolvement regularity was changing from damp-heat type to spleen and kidney deficiency type and colon blood stasis type to spleen and kidney deficiency type. The efficacy regularity was that the weight,CEA marker and quality of life on damp-heat type and colon blood stasis type could improve statistically signifi-cantwithmorechemotherapytreatmentcourseondamp-heattype.Conclusion Thereisacertainregularityonthe TCM syndrome distribution,evolvement and efficacy of colorectal cancer.